1845-11-0

• 常用中文名：萘福昔定
• 常用英文名：Nafoxidine
• CAS号：1845-11-0
• 分子式：C₂₉H₃₁NO₂
• 分子量：425.56200
• 发布时间：2018-08-29 21:34:38
• 更新时间：2024-01-08 10:40:43

名称

• 中文名: 萘福昔定
• 英文名: 1-[2-[4-(6-methoxy-2-phenyl-3,4-dihydronaphthalen-1-yl)phenoxy]ethyl]pyrrolidine
• 英文别名: Nafoxidine

物化性质

• 密度: 1.137g/cm3
• 沸点: 574.5ºC at 760mmHg
• 分子式: C₂₉H₃₁NO₂
• 分子量: 425.56200
• 闪点: 176.7ºC
• 精确质量: 425.23500
• PSA: 21.70000
• LogP: 6.01300
• 外观性状: 固体
• 储存条件: -20°C， 密封， 干燥

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UY0880000 CHEMICAL NAME : Pyrrolidine, 1-(2-(p-(3,4-dihydro-6-methoxy-2-phenyl-1-naphthyl)ph enoxy)ethyl)- CAS REGISTRY NUMBER : 1845-11-0 BEILSTEIN REFERENCE NO. : 1440873 LAST UPDATED : 199612 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C29-H31-N-O2 MOLECULAR WEIGHT : 425.61 WISWESSER LINE NOTATION : L66 BUT&J CR& HO1 BR DO2- AT5NTJ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 500 ug/kg TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Reproductive - Tumorigenic effects - uterine tumors TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Parenteral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 200 ug/kg TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Reproductive - Tumorigenic effects - uterine tumors TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 500 ug/kg SEX/DURATION : female 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Maternal Effects - other effects TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 250 ug/kg SEX/DURATION : female 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - menstrual cycle changes or disorders TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular DOSE : 3500 ug/kg SEX/DURATION : female 14 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Maternal Effects - menstrual cycle changes or disorders Reproductive - Maternal Effects - other effects MUTATION DATA TEST SYSTEM : Rodent - mouse DOSE/DURATION : 400 mg/kg REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 48,14,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4817 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 6 (estimated) No. of Female Employees: 6 (estimated)

安全

• 海关编码: 2933990090

合成路线

1729-38-0 7250-67-1 ~79% 1845-11-0

文献：Nakata, Kenya; Sano, Yoshiyuki; Shiina, Isamu Molecules, 2010 , vol. 15, # 10 p. 6773 - 6794

1081-73-8 1769-84-2 ~28% 1845-11-0

文献：LEK PHARMACEUTICALS D.D.; GAZIC SMILOVIC, Ivana; SEECHURN, Carin; COLACOT, Thomas J. Patent: WO2012/159981 A2, 2012 ; Location in patent: Page/Page column 20-21 ;

180915-95-1 98-80-6 ~% 1845-11-0

文献：GLENMARK GENERICS LIMITED; KHAN, Mubeen Ahmed; TRIVEDI, Nikhil Rasiklal; KANDASAMY, Nagan Nirmalan; PATIL, Dayaghan Gangadhar; PANDEY, Vipin Kumar; SINHA, Sukumar Patent: WO2010/125578 A2, 2010 ; Location in patent: Page/Page column 20; 21 ;

5050-41-9 1729-38-0 ~81% 1845-11-0

文献：Sano, Yoshiyuki; Nakata, Kenya; Otoyama, Takafumi; Umeda, Sei; Shiina, Isamu Chemistry Letters, 2007 , vol. 36, # 1 p. 40 - 41

123-75-1 1449689-98-8 ~85% 1845-11-0

文献：Walkinshaw, Andrew J.; Xu, Wenshu; Suero, Marcos G.; Gaunt, Matthew J. Journal of the American Chemical Society, 2013 , vol. 135, # 34 p. 12532 - 12535

1078-19-9 ~% 1845-11-0

文献：LEK PHARMACEUTICALS D.D.; GAZIC SMILOVIC, Ivana; SEECHURN, Carin; COLACOT, Thomas J. Patent: WO2012/159981 A2, 2012 ;

17878-44-3 ~% 1845-11-0

文献：Bindal, Rajeshwar D.; Durani, S.; Kapil, Randhir S.; Anand, Nitya Synthesis, 1982 , # 5 p. 405 - 407

1769-84-2 ~% 1845-11-0

文献：Bindal, Rajeshwar D.; Durani, S.; Kapil, Randhir S.; Anand, Nitya Synthesis, 1982 , # 5 p. 405 - 407

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%