681482-24-6

• 常用中文名：1-benzyl-4-[4-(trifluoromethyl)phenyl]-3,6-dihydro-2H-pyridine
• 常用英文名：1-benzyl-4-[4-(trifluoromethyl)phenyl]-3,6-dihydro-2H-pyridine
• CAS号：681482-24-6
• 分子式：C₁₉H₁₈F₃N
• 分子量：317.34800
• 发布时间：2016-05-21 08:29:23
• 更新时间：2025-11-06 15:37:58

名称

• 英文名: 1-benzyl-4-[4-(trifluoromethyl)phenyl]-3,6-dihydro-2H-pyridine

物化性质

• 分子式: C₁₉H₁₈F₃N
• 分子量: 317.34800
• 精确质量: 317.13900
• PSA: 3.24000
• LogP: 4.93260

合成路线

58778-51-1 ~98% 681482-24-6

文献：PFIZER PRODUCTS INC. Patent: WO2008/12623 A1, 2008 ; Location in patent: Page/Page column 67-68 ; WO 2008/012623 A1

936231-01-5 402-43-7 ~82% 681482-24-6

文献：JANSSEN PHARMACEUTICA N.V. Patent: WO2008/79255 A1, 2008 ; Location in patent: Page/Page column 28-29 ;

936231-01-5 455-13-0 ~10% 681482-24-6

文献：JANSSEN PHARMACEUTICA N.V. Patent: WO2008/79255 A1, 2008 ; Location in patent: Page/Page column 19-22 ;

3612-20-2 ~28% 681482-24-6

文献：KALYSPSYS, INC.; NOBLE, Stewart A.; OSHIRO, Guy; MALECHA, James W.; ZHAO, Cunxiang; ROBINSON, Carmen K. M.; DURON, Sergio G.; SERTIC, Michael; LINDSTROM, Andrew; SHIAU, Andrew; BAYNE, Christopher; KAHRAMAN, Mehmet; LOU, Boliang; GOVEK, Steven Patent: WO2006/55187 A1, 2006 ; Location in patent: Page/Page column 42-43 ; WO 2006/055187 A1

3612-20-2 402-43-7 ~% 681482-24-6

文献：Zhang, Lei; Brodney, Michael A.; Candler, John; Doran, Angela C.; Duplantier, Allen J.; Efremov, Ivan V.; Evrard, Edel; Kraus, Kenneth; Ganong, Alan H.; Haas, Jessica A.; Hanks, Ashley N.; Jenza, Keith; Lazzaro, John T.; Maklad, Noha; McCarthy, Sheryl A.; Qian, Weimin; Rogers, Bruce N.; Rottas, Melinda D.; Schmidt, Christopher J.; Siuciak, Judith A.; Tingley III, F. David; Zhang, Andy Q. Journal of Medicinal Chemistry, 2011 , vol. 54, # 6 p. 1724 - 1739

402-43-7 ~% 681482-24-6

文献：Nencetti, Susanna; Mazzoni, Maria R.; Ortore, Gabriella; Lapucci, Annalina; Giuntini, Janette; Orlandini, Elisabetta; Banti, Irene; Nuti, Elisa; Lucacchini, Antonio; Giannaccini, Gino; Rossello, Armando European Journal of Medicinal Chemistry, 2011 , vol. 46, # 3 p. 825 - 834

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58778-51-1 402-43-7 455-13-0 3612-20-2
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