1169-79-5

• 常用中文名：奎雌醇
• 常用英文名：quinestradol
• CAS号：1169-79-5
• 分子式：C₂₃H₃₂O₃
• 分子量：356.49800
• 相关类别： 原料药 激素及调节内分泌功能类药 雌激素及孕激素类药
• 发布时间：2018-09-04 05:39:08
• 更新时间：2024-01-13 15:57:22

名称

• 中文名: 奎雌醇
• 英文名: (16α,17β)-3-(Cyclopentyloxy)estra-1,3,5(10)-triene-16,17-diol
• 英文别名: 4-oxo-3,4-dihydroquinazoline-2-carboxylic acid; 3-cyclopentyl ether of estriol; EINECS 214-623-2; quinazolone-2-carboxylic acid; Oestriol-3-cyclopentylaether; Quinestradiol; 3,4-dihydro-4-oxoquinazoline-2-carboxylic acid; 4-Chinazolon-2-carbonsaeure; 4-Quinazolone-2-carboxylic Acid; 4-Oxo-3,4-dihydro-chinazolin-2-carbonsaeure; Chinazol-4-on-2-carbonsaeure

物化性质

• 密度: 1.188 g/cm3
• 沸点: 510.2ºC at 760 mmHg
• 熔点: 98-100ºC
• 分子式: C₂₃H₃₂O₃
• 分子量: 356.49800
• 闪点: 262.3ºC
• 精确质量: 356.23500
• PSA: 49.69000
• LogP: 4.19580
• 蒸汽压: 3.12E-11mmHg at 25°C
• 折射率: 1.597
• 分子结构:

  1、 摩尔折射率：102.31

  2、 摩尔体积（cm³/mol）：299.9

  3、 等张比容（90.2K）：791.2

  4、 表面张力（dyne/cm）：48.4

  5、 极化率（10-24cm3）：40.56

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : KG7395000 CHEMICAL NAME : Estra-1,3,5(10)-triene-16-alpha,17-beta-diol, 3-(cyclopentyloxy)- CAS REGISTRY NUMBER : 1169-79-5 LAST UPDATED : 198910 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C23-H32-O3 MOLECULAR WEIGHT : 356.55 WISWESSER LINE NOTATION : L E5 B666TTT&J E1 FQ GQ OO- AL5TJ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 713 ug/kg SEX/DURATION : female 16-19 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - urogenital system REFERENCE : AOGMAU Annali di Ostetricia, Ginecologia, Medicina Perinatale. (Istiuti Clinica di Perfezionamento di Milano, Via Daverio, 6, 20122 Milan, Italy) V.93- 1972- Volume(issue)/page/year: 96,83,1975 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 500 ug/kg SEX/DURATION : female 1 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) REFERENCE : STEDAM Steroids. (Holden-Day Inc., 4432 Telegraph Ave., Oakland, CA 94609) V.1- 1963- Volume(issue)/page/year: 20,223,1972

合成路线

137-43-9 50-27-1 7732-18-5 ~90% 1169-79-5

文献：Gueritee; Nicolas Patent: US4110324 A1, 1978 ;

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