1061307-56-9

• 常用中文名：R-Α,Α-双(3,5-二三氟甲基苯基)脯氨醇三乙基硅醚
• 常用英文名：R-2-[bis[3,5-bis(trifluoromethyl)phenyl][(triethylsilyl)oxy]Methyl]-Pyrrolidine
• CAS号：1061307-56-9
• 分子式：C₂₇H₂₉F₁₂NOSi
• 分子量：639.59200
• 发布时间：2017-02-01 03:12:15
• 更新时间：2026-08-04 11:03:49

名称

• 中文名: R-Α,Α-双(3,5-二三氟甲基苯基)脯氨醇三乙基硅醚
• 英文名: [bis[3,5-bis(trifluoromethyl)phenyl]-[(2R)-pyrrolidin-2-yl]methox y]-triethyl-silane
• 中文别名: (2R)-2-[二[3,5-二(三氟甲基)苯基][(三乙基硅烷基)氧基]甲基]吡咯烷; (R)-Α,Α-双(3,5-二三氟甲基苯基)脯氨醇三乙基硅醚; 鲁索利替尼杂质66
• 英文别名: Pyrrolidine, 2-[bis[3,5-bis(trifluoromethyl)phenyl][(triethylsilyl)oxy]methyl]-, (2R); R-2-[bis[3,5-bis(trifluoroMethyl)phenyl] [(triethylsilyl)oxy]Methyl]-Pyrrolidine; Ruxolitinib Impurity 66; (2R)-2-[Bis[3,5- bis(trifluoromethyl)phenyl][(triethylsilyl)oxy]methyl]pyrr olidine,e.e; Z-D-ALANINE-NH2; D-Z-Alanine amide; (2R)-2-[Di[3,5-bis(trifluoromethyl)phenyl][(triethylsilyl)oxy]methyl]pyrrolidine; Cbz-D-Ala-NH2; CBZ-D-ALANINAMIDE; Z-D-ALANINE AMIDE; (2R)-2-[Bis[3,5-bis(trifluoromethyl)phenyl][(triethylsilyl)oxy]methyl]pyrrolidine

物化性质

• 分子式: C₂₇H₂₉F₁₂NOSi
• 分子量: 639.59200
• 精确质量: 639.18300
• PSA: 21.26000
• LogP: 10.10800
• 储存条件: 室温

合成路线

948595-00-4 79271-56-0 ~96% 1061307-56-9

文献：Zhou, Jiacheng; Liu, Pingli; Lin, Qiyan; Metcalf, Brian W.; Meloni, David; Pan, Yongchun; Xia, Michael; Li, Mei; Yue, Tai-Yuen; Rodgers, James D.; Wang, Haisheng Patent: US2010/190981 A1, 2010 ; Location in patent: Page/Page column 67-68 ; US 20100190981 A1

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