5349-28-0

• 常用中文名：Acetic acid,2-thiocyanato-, ethyl ester
• 常用英文名：Acetic acid,2-thiocyanato-, ethyl ester
• CAS号：5349-28-0
• 分子式：C₅H₇NO₂S
• 分子量：145.18000
• 发布时间：2016-05-08 06:49:42
• 更新时间：2025-08-28 13:02:13

名称

• 英文名: ethyl 2-thiocyanatoacetate
• 英文别名: Rhodanessigsaeure-aethylester; Ethyl thiocyanatoacetate; Thiocyano-essigsaeure-aethyl-ester; Thiocyanato-essigsaeure-aethylester; Ethyl thiocyanoacetate; Thiocyanatoacetic acid ethyl ester; S-Cyan-thioglykolsaeure-aethylester

物化性质

• 密度: 1.19g/cm3
• 沸点: 224.1ºC at 760mmHg
• 分子式: C₅H₇NO₂S
• 分子量: 145.18000
• 闪点: 89.4ºC
• 精确质量: 145.02000
• PSA: 75.39000
• LogP: 0.76378
• 折射率: 1.547
• 储存条件: 库房通风低温干燥,与食品原料分开储运

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : AJ6200000 CHEMICAL NAME : Acetic acid, thiocyanato-, ethyl ester CAS REGISTRY NUMBER : 5349-28-0 BEILSTEIN REFERENCE NO. : 1761202 LAST UPDATED : 199712 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C5-H7-N-O2-S MOLECULAR WEIGHT : 145.19 WISWESSER LINE NOTATION : NCS1VO2 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 20 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 16,870,1966 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 52 mg/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation REFERENCE : JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951- Volume(issue)/page/year: 3,99,1954 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 18300 ug/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation REFERENCE : JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951- Volume(issue)/page/year: 3,99,1954 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 39100 ug/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes REFERENCE : JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951- Volume(issue)/page/year: 3,99,1954 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 6 mg/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation REFERENCE : JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951- Volume(issue)/page/year: 3,99,1954 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 10 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - other changes REFERENCE : JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951- Volume(issue)/page/year: 3,99,1954 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Bird - pigeon DOSE/DURATION : 20 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951- Volume(issue)/page/year: 3,99,1954

安全

• 海关编码: 2930909090

合成路线

333-20-0 105-39-5 ~97% 5349-28-0

文献：Chen, Li; Chen, Shaoqing; Michoud, Christophe Patent: US2006/63804 A1, 2006 ; Location in patent: Page/Page column 14 ; US 20060063804 A1

105-36-2 ~99% 5349-28-0

文献：Li, Jing; Cao, Jing-Jing; Wei, Jun-Fa; Shi, Xian-Ying; Zhang, Li-Hui; Feng, Jin-Juan; Chen, Zhan-Guo European Journal of Organic Chemistry, 2011 , # 2 p. 229 - 233

333-20-0 105-36-2 ~79% 5349-28-0

文献：Kakehi, Akikazu; Ito, Suketaka; Hashimoto, Yasunobu Bulletin of the Chemical Society of Japan, 1996 , vol. 69, # 6 p. 1769 - 1776

105-36-2 2911-22-0 ~74% 5349-28-0

文献：Yamamoto, Yutaka; Morita, Yasuo Chemical & Pharmaceutical Bulletin, 1984 , vol. 32, # 8 p. 2957 - 2962

1147550-11-5 105-39-5 ~% 5349-28-0

文献：Farbw.Hoechst. Patent: DE836646 , 1951 ; DRP/DRBP Org.Chem.

623-73-4 333-20-0 ~% 5349-28-0

文献：Holmberg Chemische Berichte, 1914 , vol. 47, p. 162

64-17-5 333-20-0 105-39-5 ~% 5349-28-0

文献：Heintz Justus Liebigs Annalen der Chemie, 1865 , vol. 136, p. 223

623-73-4 7664-93-9 333-20-0 ~% 5349-28-0

文献：Holmberg Chemische Berichte, 1914 , vol. 47, p. 162

上下游产品

上游产品  7
333-20-0 105-39-5 105-36-2 2911-22-0
623-73-4 64-17-5 7664-93-9
下游产品  10
27032-01-5 623-51-8 23969-11-1 2295-31-0
542-90-5 105-36-2 623-48-3 556-90-1
31101-37-8 141-84-4

海关

海关编码	2930909090
中文概述	2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%