中文名 |
多抗霉素
|
英文名 |
polyoxin b
|
中文别名 |
保利霉素
多效霉素
多氧霉素
肽嘧啶核苷
宝丽安
多氧霉素B
多克菌
|
英文别名 |
piomycin
Polyoxin AL
POLYXIN
|
密度 |
1.774 g/cm3 |
分子式 |
C17H25N5O13 |
分子量 |
507.40600 |
精确质量 |
507.14500 |
PSA |
309.98000 |
折射率 |
1.669 |
储存条件 |
2-8°C,避光,保存于惰性气体中 |
稳定性 |
原药为浅褐色粉末。易溶于水,不溶于有机溶剂。对紫外线稳定,在酸性和中性溶液中稳定,但在碱性溶液中不稳定。 |
分子结构 |
1、 摩尔折射率:106.73
2、 摩尔体积(cm3/mol):285.9
3、 等张比容(90.2K):930.5
4、 表面张力(dyne/cm):112.1
5、 极化率(10-24cm3):42.31 |
CHEMICAL IDENTIFICATION
-
RTECS NUMBER :
-
BA2927000
-
CHEMICAL NAME :
-
Allofuranuronic acid, 5-(2-amino-2-deoxy-L-xylonamido)-1,5-dideoxy-1-(3,4-d ihydro-5- (hydroxymethyl)-2,4-dioxo-1(2H)-pyrimidinyl)-, monocarbamate (ester), beta-D-
-
CAS REGISTRY NUMBER :
-
19396-06-6
-
LAST UPDATED :
-
199204
-
DATA ITEMS CITED :
-
5
-
MOLECULAR FORMULA :
-
C17-H25-N5-O13
-
MOLECULAR WEIGHT :
-
507.47
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
14665 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
REFERENCE :
-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C244,1991
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Administration onto the skin
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
>20 gm/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
REFERENCE :
-
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,696,1991
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
15638 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
REFERENCE :
-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C244,1991
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Administration onto the skin
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
>1200 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
REFERENCE :
-
JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (40),32,1982
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intravenous
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
200 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
REFERENCE :
-
85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,245,1981
|
【方法1】
多抗霉素生物合成的工艺过程:
砂土管菌种→斜面菌种[10~14d,26℃]→摇瓶种子[36~48h,28℃]→种子罐种子[24h,28℃]→发酵[90~120h,28℃]放罐,发酵液酸化(pH值为3~4)→浓缩→干燥→包装
菌种 金色产色链霉菌(Streptomyces aureo chromogenes)。
斜面菌种培养 斜面培养基配方如下。
麦芽糖 0.5%; 玉米粉 0.5%; 酵母膏 0.4%; 琼脂 2%; pH值 6.3,接种后于26℃培养10~14d。
摇瓶种子培养 培养基配方:黄豆饼粉(冷榨)5%;豆油2%;葡萄糖 1%;KH2PO4 0.1%
调pH值6.5后加碳酸钙0.3%。罐压4.9×10Pa,罐温28℃,通气量1:1,机械搅拌培养24h。发酵罐发酵 培养基配方:
黄豆饼粉 2%;玉米粉 1.5%; 饴糖 4%;酵母粉 0.4%;鱼粉 0.5%;氯化钠 0.1%;消泡油 0.5%
调pH值6.5后加碳酸钙0.3%。罐压0.05MPa,罐温28℃,通气量1:1 (前、后期少些,中期多些),发酵时间90~120h。放罐后加草酸酸化,pH值3~4。
发酵液浓缩 发酵液酸化后用真空薄膜浓缩器进行减压浓缩。料液温度40~60℃,压力为1.33×10-4~1.47×10-4Pa,流量250kg/h。
干燥、包装 浓缩液打入干燥塔喷雾干燥。进干燥塔热风温度150℃,排风温度75℃,塔内负压,原粉经粉碎,用滑石粉调整效价为1.5×10单位(1.5%)出厂。