14346-24-8

• 常用中文名：5,6,7,8-四氢-[1]-苯并噻吩[2,3-d]嘧啶-4(1h)-酮
• 常用英文名：[1]Benzothieno[2,3-d]pyrimidin-4(1H)-one,5,6,7,8-tetrahydro-
• CAS号：14346-24-8
• 分子式：C₁₀H₁₀N₂OS
• 分子量：206.264
• 发布时间：2018-12-18 17:03:41
• 更新时间：2024-01-02 05:01:05

名称

• 中文名: 5,6,7,8-四氢-[1]-苯并噻吩[2,3-d]嘧啶-4(1h)-酮
• 英文名: 5,6,7,8-tetrahydro-3H-[1]benzothiolo[2,3-d]pyrimidin-4-one
• 英文别名: 5,6,7,8-Tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(1H)-one; [1]Benzothieno[2,3-d]pyrimidin-4(3H)-one, 5,6,7,8-tetrahydro-; 4-oxo-3,4,5,6,7,8-hexahydrobenzo<b>thieno<2,3-d>pyrimidine; [1]benzothieno[2,3-d]pyrimidin-4(1H)-one, 5,6,7,8-tetrahydro-; 5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-ol; [1]Benzothieno[2,3-d]pyrimidin-4-ol, 5,6,7,8-tetrahydro-; 4-oxo-3,4,5,6,7,8-hexahydrobenzothieno<2,3-d>pyrimidine; 4-oxo-3,4,5,6,7,8-hexahydro-1,3,4b-triaza-fluorene-9-carbonitrile

物化性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 490.4±45.0 °C at 760 mmHg
• 分子式: C₁₀H₁₀N₂OS
• 分子量: 206.264
• 闪点: 250.4±28.7 °C
• 精确质量: 206.051376
• PSA: 73.99000
• LogP: 2.13
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.810

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DL8354000 CHEMICAL NAME : (1)Benzothieno(2,3-d)pyrimidin-4(1H)-one, 5,6,7,8-tetrahydro- CAS REGISTRY NUMBER : 14346-24-8 LAST UPDATED : 199406 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C10-H10-N2-O-S MOLECULAR WEIGHT : 206.28 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 19,420,1984

安全

• 海关编码: 2934999090

合成路线

4506-71-2 77287-34-4 ~99% 14346-24-8

文献：Nirogi, Ramakrishna V.S.; Kambhampati, Sastri Rama; Kothmirkar, Prabhakar; Arepalli, Sobhanadri; Pamuleti, Narasimha Reddy G.; Shinde, Anil K.; Dubey Synthetic Communications, 2011 , vol. 41, # 19 p. 2835 - 2851

4651-91-6 64-18-6 ~77% 14346-24-8

文献：National Health Research Institutes Patent: US2010/120805 A1, 2010 ; Location in patent: Page/Page column 42-43 ; US 20100120805 A1

77287-34-4 108354-78-5 ~79% 14346-24-8

文献：PRESIDENT AND FELLOWS OF HARVARD COLLEGE; FINLEY, Daniel; KING, Randall, W.; LEE, Byung-Hoon; LEE, Min, Jae; GAHMAN, Timothy, C. Patent: WO2012/12712 A2, 2012 ; Location in patent: Page/Page column 48 ;

109-94-4 4815-28-5 ~96% 14346-24-8

文献：Miyashita, Akira; Fujimoto, Katsuhiro; Okada, Tomomi; Higashino, Takeo Heterocycles, 1996 , vol. 42, # 2 p. 691 - 699

108-94-1 ~% 14346-24-8

文献：European Journal of Medicinal Chemistry, , vol. 46, # 3 p. 870 - 876

122-51-0 4815-28-5 ~93% 14346-24-8

文献：Briel; Rybak; Kronbach; Unverferth Pharmazie, 2008 , vol. 63, # 11 p. 823 - 826

77287-34-4 4815-28-5 ~74% 14346-24-8

文献：Romashov, Leonid V.; Zeifman, Alexey A.; Zakharenko, Alexandra L.; Novikov, Fedor N.; Stroilov, Viktor S.; Stroganov, Oleg V.; Chilov, Germes G.; Khodyreva, Svetlana N.; Lavrik, Olga I.; Titov, Ilya Yu.; Svitan'Ko, Igor V. Mendeleev Communications, 2012 , vol. 22, # 1 p. 15 - 17

40493-18-3 ~% 14346-24-8

文献：Pharmazie, , vol. 41, # 1 p. 23 - 25

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%