521059-17-6

• 常用中文名：2-(1-hydroxysilinan-1-yl)-2-(4-methoxyphenyl)-N,N-dimethylethanamine
• 常用英文名：2-(1-hydroxysilinan-1-yl)-2-(4-methoxyphenyl)-N,N-dimethylethanamine
• CAS号：521059-17-6
• 分子式：C₁₆H₂₇NO₂Si
• 分子量：293.47700
• 发布时间：2016-07-02 20:32:47
• 更新时间：2025-08-26 11:20:22

名称

• 英文名: 2-(1-hydroxysilinan-1-yl)-2-(4-methoxyphenyl)-N,N-dimethylethanamine
• 英文别名: Rac-Sila-Venlafaxine; Silacyclohexan-1-ol,1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]

物化性质

• 分子式: C₁₆H₂₇NO₂Si
• 分子量: 293.47700
• 精确质量: 293.18100
• PSA: 32.70000
• LogP: 3.09680

合成路线

781626-14-0 124-40-3 ~88% 521059-17-6

文献：AMEDIS PHARMACEUTICALS LTD. Patent: WO2004/94436 A1, 2004 ; Location in patent: Page 14-15 ;

521059-16-5 ~83% 521059-17-6

文献：Showell, Graham A.; Barnes, Matthew J.; Daiss, Juergen O.; Mills, John S.; Montana, John G.; Tacke, Reinhold; Warneck, Julie B. H. Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 9 p. 2555 - 2558

2406-34-0 ~% 521059-17-6

文献：Showell, Graham A.; Barnes, Matthew J.; Daiss, Juergen O.; Mills, John S.; Montana, John G.; Tacke, Reinhold; Warneck, Julie B. H. Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 9 p. 2555 - 2558

781626-14-0 ~% 521059-17-6

文献：Showell, Graham A.; Barnes, Matthew J.; Daiss, Juergen O.; Mills, John S.; Montana, John G.; Tacke, Reinhold; Warneck, Julie B. H. Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 9 p. 2555 - 2558

781626-12-8 ~% 521059-17-6

文献：Showell, Graham A.; Barnes, Matthew J.; Daiss, Juergen O.; Mills, John S.; Montana, John G.; Tacke, Reinhold; Warneck, Julie B. H. Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 9 p. 2555 - 2558

781626-13-9 ~% 521059-17-6

文献：Showell, Graham A.; Barnes, Matthew J.; Daiss, Juergen O.; Mills, John S.; Montana, John G.; Tacke, Reinhold; Warneck, Julie B. H. Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 9 p. 2555 - 2558

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