61-24-5

• 常用中文名：头孢菌素 C
• 常用英文名：Cephalosporin C
• CAS号：61-24-5
• 分子式：C₁₆H₂₁N₃O₈S
• 分子量：415.418
• 相关类别： 分析化学 标准品 法医和兽医标准品
• 发布时间：2018-04-27 08:00:00
• 更新时间：2024-01-04 11:51:32
• 对金葡菌、伤寒杆菌、大肠杆菌有活性。但由于抗菌活力低，临床未广泛应用。但通过改造可获得高效衍生物，目前主要作为制备7-氨基头孢霉烷酸（7-ACA）的中间体。 
  

名称

• 中文名: 头孢菌素 C
• 英文名: cephalosporin C
• 中文别名: 头孢菌素C
• 英文别名: 4-27-00-05902; cephalosphorin C; 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-[(5-amino-5-carboxy-1-oxopentyl)amino]-8-oxo-, (6R,7R)-; [6R-[6a,7b(R*)]]-3-[(Acetyloxy)methyl]-7-[(5-amino-5-carboxy-1-oxopentyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid; cephalosporn C; Centropazine; Cephalosporin; Cephalosporin C; (6R,7R)-3-(Acetoxymethyl)-7-[(5-amino-5-carboxypentanoyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-3-(Acetoxymethyl)-7-[(5-amino-5-carboxypentanoyl)amino]-8 -oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 7-(D-5-Amino-5-carboxyvaleramido)-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Acetate; cefalosporin C; Centpropazine; (6R,7R)-3-[(acetyloxy)methyl]-7-[(5-amino-5-carboxypentanoyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

物化性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 814.7±65.0 °C at 760 mmHg
• 分子式: C₁₆H₂₁N₃O₈S
• 分子量: 415.418
• 闪点: 446.5±34.3 °C
• 精确质量: 415.104950
• PSA: 205.12000
• LogP: -0.20
• 蒸汽压: 0.0±6.3 mmHg at 25°C
• 折射率: 1.639

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : XI0331650 CHEMICAL NAME : 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(5-amino-5-carboxyvaleramido)-3- (hydroxymethyl)-8-oxo-, acetate (ester) CAS REGISTRY NUMBER : 61-24-5 BEILSTEIN REFERENCE NO. : 0065348 LAST UPDATED : 199612 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C16-H21-N3-O8-S MOLECULAR WEIGHT : 415.46 WISWESSER LINE NOTATION : T46 ANV ES GUTJ CMV3YZVQ G1OV1 HVQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 4(1),96,1980 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.3 mg/m3 JAN 1993

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