465-90-7

• 常用中文名：Hellebrigenin
• 常用英文名：Bufotalidin
• CAS号：465-90-7
• 分子式：C₂₄H₃₂O₆
• 分子量：416.50700
• 相关类别： 信号通路 细胞凋亡 细胞凋亡
• 发布时间：2017-01-04 10:43:18
• 更新时间：2025-08-27 11:21:30
• Hellebrigenin,属于心脏活性类固醇的丁二烯内酯之一,从中药中分离出来。Hellebrigenin 诱导 DNA 损伤和细胞周期 G2/M 阻滞。 Hellebrigenin 触发线粒体介导的细胞凋亡。

名称

• 中文名: 蟾蜍它里定
• 英文名: hellebrigenin
• 英文别名: (3S,5S,8R,9S,10S,13R,14S,17R)-3,5,14-trihydroxy-13-methyl-17-(6-oxopyran-3-yl)-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-10-carbaldehyde; EINECS 207-368-3; Bufotalidin; Hellebrigenin; Gellebrigenin

物化性质

• 密度: 1.419g/cm3
• 沸点: 626.3ºC at 760 mmHg
• 熔点: 175 °C
• 分子式: C₂₄H₃₂O₆
• 分子量: 416.50700
• 闪点: 215ºC
• 精确质量: 416.22000
• PSA: 107.97000
• LogP: 2.53580
• 外观性状: 白色粉末
• 折射率: 1.675
• 储存条件: 2-8°C，密封，干燥

生物活性

• 描述: Hellebrigenin,属于心脏活性类固醇的丁二烯内酯之一,从中药中分离出来。Hellebrigenin 诱导 DNA 损伤和细胞周期 G2/M 阻滞。 Hellebrigenin 触发线粒体介导的细胞凋亡。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
• 参考文献:

  [1]. Deng LJ, et al. Hellebrigenin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells through inhibition of Akt. Chem Biol Interact. 2014 Aug 5;219:184-94.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : EI3175800 CHEMICAL NAME : 5-beta-Bufa-20,22-dienolide, 3-beta,5,14-trihydroxy-19-oxo- CAS REGISTRY NUMBER : 465-90-7 BEILSTEIN REFERENCE NO. : 0056259 LAST UPDATED : 199709 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C24-H32-O6 MOLECULAR WEIGHT : 416.56 WISWESSER LINE NOTATION : L E5 B666TJ AVH E1 IQ MQ OQ F- ET6OVJ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 77 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PHUZBI Pharmazie in Unserer Zeit. (VCH Pub., Inc., 303 N.W. 12th Ave., Deerfield Beach, FL 33441) V.1- 1972- Volume(issue)/page/year: 13,129,1984 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 1345 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 252,314,1966 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : 514 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : APJUA8 Acta Pharmaceutica Jugoslavica. (FDH, Masarykova 2, 41000 Zagreb, Yugoslavia) V.1-41, 1951-1991. Volume(issue)/page/year: 24,179,1974 *** REVIEWS *** TOXICOLOGY REVIEW 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,191,1963