70578-24-4

• 常用中文名：滇乌头碱
• 常用英文名：Yunaconitine
• CAS号：70578-24-4
• 分子式：C₃₅H₄₉NO₁₁
• 分子量：659.764
• 相关类别： 生物化工 中草药成分
• 发布时间：2018-06-26 09:04:06
• 更新时间：2024-01-02 20:36:55
• Yunaconitine(Guayewuanine B) 是一种剧毒的乌头类生物碱。

名称

• 中文名: 滇乌头碱
• 英文名: Yunaconitine
• 英文别名: Benzoic acid, 4-methoxy-, (1α,3α,6α,14α,16β)-8-(acetyloxy)-20-ethyl-3,13-dihydroxy-1,6,16-trimethoxy-4-(methoxymethyl)aconitan-14-yl ester; yunnaconitine; (1α,3α,6α,14α,16β)-8-(acetyloxy)-20-ethyl-3,13-dihydroxy-1,6,16-trimethoxy-4-(methoxymethyl)aconitan-14-yl 4-methoxybenzoate; yunacotinine; Yunaconitine; (1α,3α,6α,14α,16β)-8-Acetoxy-20-ethyl-3,13-dihydroxy-1,6,16-trimethoxy-4-(methoxymethyl)aconitan-14-yl 4-methoxybenzoate

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 722.8±60.0 °C at 760 mmHg
• 熔点: 142-144ºC
• 分子式: C₃₅H₄₉NO₁₁
• 分子量: 659.764
• 闪点: 390.9±32.9 °C
• 精确质量: 659.330566
• PSA: 142.45000
• LogP: 0.61
• 蒸汽压: 0.0±2.5 mmHg at 25°C
• 折射率: 1.599
• 储存条件: 2-8℃

生物活性

• 描述: Yunaconitine(Guayewuanine B) 是一种剧毒的乌头类生物碱。
• 相关类别:
  信号通路 >> 其他 >> 其他
  天然产物 >> 生物碱
  研究领域 >> 其他

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : AR5566500 CHEMICAL NAME : Aconitane-3,8,13,14-tetrol, 20-ethyl-4-(methoxymethyl)-1,6,16-trimethoxy-, 8-acetate 14- (4-methoxybenzoate), (1-alpha,3-alpha,6-alpha,14-alpha,16-beta)- CAS REGISTRY NUMBER : 70578-24-4 LAST UPDATED : 199412 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C35-H49-N-O11 MOLECULAR WEIGHT : 659.85 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 50 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 14,872,1989 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 585 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 14,872,1989 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 260 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 4,247,1981 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 50 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 4,247,1981 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 30 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 4,247,1981

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