1010-61-3

• 常用中文名：4-Quinolinamine,N-hydroxy-, 1-oxide, hydrochloride (1:1)
• 常用英文名：4-Quinolinamine,N-hydroxy-, 1-oxide, hydrochloride (1:1)
• CAS号：1010-61-3
• 分子式：C₉H₉ClN₂O₂
• 分子量：212.63300
• 发布时间：2017-02-24 03:36:30
• 更新时间：2024-01-18 09:19:53

名称

• 英文名: 4-hydroxyaminoquinoline n-oxide hydrochloride
• 英文别名: (S)-N-(1-methyloxycarbonyl-2-methyl-prop-1-yl)-N-pentanoyl-N-[2'(1H-tetrazol-5-yl)biphenyl-4-yl-methyl]amine; N-(1-oxy-[4]quinolyl)-hydroxylamine,hydrochloride; (S)-methyl 2-(N-((2'-(1H-tetrazol-5-yl)-biphenyl-4-yl)methyl)pentanamido)-3-methylbutanoate; N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine methyl ester; (2S)-methyl 3-methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]butanoate; N-(1-Oxy-[4]chinolyl)-hydroxylamin,Hydrochlorid; (S)-Methyl 2-(N-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoate; N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine methyl ester; (S)-N-(1-Methoxycarbonyl-2-methyl-prop-1-yl)-N-pentanoyl-N-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-amine

物化性质

• 分子式: C₉H₉ClN₂O₂
• 分子量: 212.63300
• 精确质量: 212.03500
• PSA: 57.72000
• LogP: 2.94440
• 蒸汽压: 2.94E-05mmHg at 25°C

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : VC0175000 CHEMICAL NAME : Quinoline, 4-(hydroxyamino)-, 1-oxide, hydrochloride CAS REGISTRY NUMBER : 1010-61-3 LAST UPDATED : 199410 DATA ITEMS CITED : 12 MOLECULAR FORMULA : C9-H8-N2-O2.Cl-H MOLECULAR WEIGHT : 212.65 WISWESSER LINE NOTATION : T66 BNJ BO EMQ &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 20440 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 150 mg/kg/45W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors Skin and Appendages - tumors TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 16 mg/kg/2W-I TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Tumorigenic - tumors at site of application TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 6 mg/kg TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Gastrointestinal - tumors Skin and Appendages - tumors TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 240 mg/kg/50D-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 451 ug/kg TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 7 mg/kg TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors MUTATION DATA TYPE OF TEST : Morphological transformation TEST SYSTEM : Rodent - hamster Embryo DOSE/DURATION : 2130 ug/L REFERENCE : JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 41,53,1968

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