145821-58-5

• 常用中文名：噻加宾乙酯
• 常用英文名：ethyl (3R)-1-[4,4-bis(3-methylthiophen-2-yl)but-3-enyl]piperidine-3-carboxylate
• CAS号：145821-58-5
• 分子式：C₂₂H₂₉NO₂S₂
• 分子量：403.60100
• 发布时间：2018-07-20 12:41:53
• 更新时间：2024-01-05 17:43:27

名称

• 中文名: 噻加宾乙酯
• 英文名: ethyl (3R)-1-[4,4-bis(3-methylthiophen-2-yl)but-3-enyl]piperidine-3-carboxylate
• 英文别名: tiagabine ethyl ester

物化性质

• 密度: 1.145g/cm3
• 沸点: 534.78ºC at 760 mmHg
• 分子式: C₂₂H₂₉NO₂S₂
• 分子量: 403.60100
• 闪点: 277.225ºC
• 精确质量: 403.16400
• PSA: 86.02000
• LogP: 5.46120
• 蒸汽压: 0mmHg at 25°C
• 折射率: 1.575

合成路线

1238888-42-0 177735-09-0 ~74% 145821-58-5

文献：Bartoli, Giuseppe; Cipolletti, Roberto; Di Antonio, Giustino; Giovannini, Riccardo; Lanari, Silvia; Marcolini, Mauro; Marcantoni, Enrico Organic and Biomolecular Chemistry, 2010 , vol. 8, # 15 p. 3509 - 3517

109857-81-0 25137-01-3 ~61% 145821-58-5

文献：Zheng, Jianbin; Wen, Ren; Luo, Xiaomin; Lin, Guoqiang; Zhang, Jiange; Xu, Linfeng; Guo, Lihe; Jiang, Hualiang Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 1 p. 225 - 227

14282-76-9 ~% 145821-58-5

文献：Andersen, Knud Erik; Braestrup, Claus; Groenwald, Frederik C.; Joergensen, Anker S.; Nielsen, Erik B.; et al. Journal of Medicinal Chemistry, 1993 , vol. 36, # 12 p. 1716 - 1725

922184-80-3 ~% 145821-58-5

文献：Andersen, Knud Erik; Braestrup, Claus; Groenwald, Frederik C.; Joergensen, Anker S.; Nielsen, Erik B.; et al. Journal of Medicinal Chemistry, 1993 , vol. 36, # 12 p. 1716 - 1725

5834-16-2 ~% 145821-58-5

文献：Andersen, Knud Erik; Braestrup, Claus; Groenwald, Frederik C.; Joergensen, Anker S.; Nielsen, Erik B.; et al. Journal of Medicinal Chemistry, 1993 , vol. 36, # 12 p. 1716 - 1725

30717-55-6 ~% 145821-58-5

文献：Andersen, Knud Erik; Braestrup, Claus; Groenwald, Frederik C.; Joergensen, Anker S.; Nielsen, Erik B.; et al. Journal of Medicinal Chemistry, 1993 , vol. 36, # 12 p. 1716 - 1725

148319-25-9 ~% 145821-58-5

文献：Andersen, Knud Erik; Braestrup, Claus; Groenwald, Frederik C.; Joergensen, Anker S.; Nielsen, Erik B.; et al. Journal of Medicinal Chemistry, 1993 , vol. 36, # 12 p. 1716 - 1725

148319-26-0 ~% 145821-58-5

文献：Andersen, Knud Erik; Braestrup, Claus; Groenwald, Frederik C.; Joergensen, Anker S.; Nielsen, Erik B.; et al. Journal of Medicinal Chemistry, 1993 , vol. 36, # 12 p. 1716 - 1725

上下游产品

上游产品  7
177735-09-0 109857-81-0 25137-01-3 14282-76-9
922184-80-3 5834-16-2 30717-55-6
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115103-54-3