54-49-9

• 常用中文名：间羟胺
• 常用英文名：metaraminol
• CAS号：54-49-9
• 分子式：C₉H₁₃NO₂
• 分子量：167.20500
• 相关类别： 医药中间体 杂环化合物 吡啶类化合物 氰基吡啶
• 发布时间：2018-03-14 08:00:00
• 更新时间：2024-01-04 17:00:29

名称

• 中文名: 间羟胺
• 英文名: metaraminol
• 中文别名: 阿拉明; α-(1-氨乙基)-3-羟基苯甲醇
• 英文别名: L-Metaraminol; m-Hydroxy norephedrine; Pressonex; Metaraminolum; Metaradrine; 3-[(1R,2S)-2-amino-1-hydroxypropyl]phenol; m-Hydroxypropadrine; Pressorol; 1-Metaraminol; Hydroxynorephedrine

物化性质

• 密度: 1.198g/cm3
• 沸点: 357.9ºC at 760mmHg
• 熔点: 107.5°C
• 分子式: C₉H₁₃NO₂
• 分子量: 167.20500
• 闪点: 170.3ºC
• 精确质量: 167.09500
• PSA: 66.48000
• LogP: 1.47310
• 折射率: 1.4760 (estimate)

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DN4300000 CHEMICAL NAME : Benzyl alcohol, alpha-(1-aminoethyl)-m-hydroxy-, (-)- CAS REGISTRY NUMBER : 54-49-9 LAST UPDATED : 199706 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C9-H13-N-O2 MOLECULAR WEIGHT : 167.23 WISWESSER LINE NOTATION : ZY1&YQR CQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 240 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,155,1973 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 41 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,155,1973 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 117 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,155,1973 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 99 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,155,1973 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 92 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,155,1973 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 51 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,155,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1069 No. of Facilities: 43 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 85 (estimated)

合成路线

82494-35-7 ~% 54-49-9

文献：DE570861 , ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 19, p. 1441

1940-82-5 ~% 54-49-9

文献：DE552244 , ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 18, p. 3043