222638-67-7

222638-67-7结构式

中文名	BEC盐酸盐
英文名	s-(2-boronoethyl)-l-cysteine hydrochloride
英文别名	BEC HCl BEC hydrochloride

描述	BEC HCl是一个竞争性的 Arginase II抑制剂,Ki值是0.31 uM (ph 7.5).
相关类别	信号通路 >> 免疫及炎症 >> 精氨酸研究领域 >> 癌症
参考文献	[1]. Colleluori DM et al. Classical and slow-binding inhibitors of human type II arginase. Biochemistry. 2001 Aug 7;40(31):9356-62. [2]. Kim NN et al. Probing erectile function: S-(2-boronoethyl)-L-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum. Biochemistry. 2001 Mar 6;40(9):2678-88. [3]. Karina Ckless et al. Inhibition of Arginase Activity Enhances Inflammation in Mice with Allergic Airway Disease, in Association with Increases in Protein S-Nitrosylation and Tyrosine Nitration. J Immunol. Author manuscript; available in PMC 2010 Jun 28. [4]. Steppan J et al. Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism. Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4759-64.