60153-49-3

• 常用中文名：3-(甲基亚硝胺基)丙腈
• 常用英文名：Propionitrile, 3-(methylnitrosamino).
• CAS号：60153-49-3
• 分子式：C₄H₇N₃O
• 分子量：113.11800
• 发布时间：2017-09-16 14:49:27
• 更新时间：2024-01-02 19:56:27

名称

• 中文名: 3-(甲基亚硝胺基)丙腈
• 英文名: 3-(Methylnitrosamino)propionitrile
• 英文别名: N-(2-cyanoethyl)-N-methylnitrous amide

物化性质

• 密度: 1.07g/cm3
• 沸点: 311ºC at 760 mmHg
• 分子式: C₄H₇N₃O
• 分子量: 113.11800
• 闪点: 141.9ºC
• 精确质量: 113.05900
• PSA: 56.46000
• LogP: 0.51328
• 折射率: 1.492

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UG4030000 CHEMICAL NAME : Propionitrile, 3-(methylnitrosamino)- CAS REGISTRY NUMBER : 60153-49-3 LAST UPDATED : 199612 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C4-H7-N3-O MOLECULAR WEIGHT : 113.14 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1036 mg/kg/54W-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 103 mg/kg/20W-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 622 mg/kg TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Gastrointestinal - tumors TYPE OF TEST : DNA damage MUTATION DATA TYPE OF TEST : Unscheduled DNA synthesis TEST SYSTEM : Rodent - rat Liver DOSE/DURATION : 100 mg/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 221,263,1989 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 37,263,1985 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 37,263,1985 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987

合成路线

1738-25-6 ~76% 60153-49-3

文献：Boyer, Joseph H.; Kumar, Govindarajulu; Pillai, T. Perumal Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1986 , p. 1751 - 1754

693-05-0 ~% 60153-49-3

文献：Chang,S.K. et al. Journal of Organic Chemistry, 1976 , vol. 41, p. 3752 - 3755

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