65222-35-7

• 常用中文名：帕折普汀
• 常用英文名：1,3-Propanediamine,N1,N1-diethyl-N3-(6-methyl-5H-pyrido[3',4':4,5]pyrrolo[2,3-g]isoquinolin-10-yl)-
• CAS号：65222-35-7
• 分子式：C₂₂H₂₇N₅
• 分子量：361.48300
• 发布时间：2018-05-12 08:00:00
• 更新时间：2025-08-27 10:34:04

名称

• 中文名: 帕折普汀
• 英文名: Pazelliptine
• 英文别名: Pazeliptina [Spanish]; EINECS 265-640-7; N,N-diethyl-N'-(6-methyl-5H-pyrido[3',4':4,5]pyrrolo[2,3-g]isoquinoline-10-yl)-propane-1,3-diamine; n,n-diethyl-n'-(6-methyl-5h-pyrido[3',4':4,5]pyrrolo[2,3-g]isoquinolin-10-yl)propane-1,3-diamine; 10-<<3-(diethylamino)propyl>amino>-6-methyl-5H-pyrido<3',4':4,5>pyrrolo<2,3-g>isoquinoline; BD-40; Pazelliptinum [Latin]

物化性质

• 密度: 1.21g/cm3
• 沸点: 615.2ºC at 760 mmHg
• 分子式: C₂₂H₂₇N₅
• 分子量: 361.48300
• 闪点: 325.9ºC
• 精确质量: 361.22700
• PSA: 56.84000
• LogP: 4.78950
• 折射率: 1.707

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TX7388500 CAS REGISTRY NUMBER : 65222-35-7 LAST UPDATED : 199612 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C22-H27-N5 MOLECULAR WEIGHT : 361.54 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 30 mg/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent MUTATION DATA TYPE OF TEST : DNA adduct TEST SYSTEM : Mammal - species unspecified Lymphocyte DOSE/DURATION : 17 umol/L REFERENCE : BUCABS Bulletin du Cancer. (SPPIF, B.P.22, F-41353 Vineuil, France) V.53- 1966- Volume(issue)/page/year: 67,9,1980

合成路线

58832-85-2 67398-38-3 ~76% 65222-35-7

文献：Sanofi Patent: US5079363 A1, 1992 ;

148729-96-8 104-78-9 ~87% 65222-35-7

文献：Dormoy; Heymes Tetrahedron, 1993 , vol. 49, # 14 p. 2915 - 2938

148729-96-8 ~% 65222-35-7

文献：Dormoy; Heymes Tetrahedron, 1993 , vol. 49, # 14 p. 2915 - 2938

69022-46-4 104-78-9 ~84% 65222-35-7

文献：Dormoy; Heymes Tetrahedron, 1993 , vol. 49, # 14 p. 2915 - 2938

上下游产品

上游产品  3
58832-85-2 67398-38-3 104-78-9
下游产品  0