205393-22-2

• 常用中文名：(1R)-(1S,2S,3R,5S)-P二醇-N-(N-吡嗪基苯基丙氨酰基)-1-氨基-3-甲基丁烷-1-硼酸酯
• 常用英文名：BORTEZOMIB-PINANEDIOL
• CAS号：205393-22-2
• 分子式：C₂₉H₃₉BN₄O₄
• 分子量：518.455
• 发布时间：2018-06-13 20:15:16
• 更新时间：2026-07-01 12:57:18
• Bortezomib-pinanediol is a prodrug of Bortezomib, as well as a proteasome inhibitor.

名称

• 中文名: 保特佐米蒎烷二醇酯
• 英文名: bortezomib-pinanediol
• 中文别名: BORTEZOMIB杂质I; 硼替佐米杂质I; (1R)-(1S,2S,3R,5S)-蒎烷二醇-N-(N-吡嗪基-苯基丙胺基)-1-氨基-3-甲基丁烷-1-硼酯; 硼替佐米杂质; 硼替佐米蒎烷二醇酯; N-((S)-1-(((R)-3-甲基-1-((3AS,4S,6S,7-3A,5,5-三甲基六氢-4,6-甲亚甲基苯并[D] ,3,2]二氧杂硼醇-2-基)丁基)氨基)-1-氧代-3-苯基丙烷-2-基)吡嗪-2-羧酰胺; 硼替佐米杂质54; 硼替佐米杂质98; 硼替佐米蒎烷二醇杂质; 硼替佐米二醇酯
• 英文别名: N-{(1R)-3-Methyl-1-[(1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.0]dec-4-yl]butyl}-Nα-(2-pyrazinylcarbonyl)-L-phenylalaninamide; 2-Pyrazinecboxamide, N-[(1S)-2-[[(1R)-1-[(3aS,4S,6S,7-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]; N-((S)-1-(((R)-3-Methyl-1-((3aS,4S,6S,7-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-cboxamide; BORTEZOMIB-PINANEDIOLoxoethyl]-2-pyrazinecboxamide; Bortezomib Impurity 54; (1S,2S,3R,5S)-pinanedioxy-N-pyrazinoyl-D-phenylalanyl-L-leucineboronate; (1R)-(1S,2S,3R,5S)-Pinanediol-N-(N-pyrazinylphenylalaninoyl)-1-amino-3-methyl-butane-1-boronate; BortezoMib VI; Bortezomib pinanediol ester; BortezoMib InterMediate III (BortezoMib pinanediol ester); BortezoMib interMediates N-1; Bortezomib Pinanediol Impurity; N-[(1S)-2-[[(1R)-1-[(3aS,4S,6S,7-Hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-2-pyrazinecboxamide; Bortezomib Impurity; Bortezomib intermediates III; Bortezomib impurity 4/Bortezomib Pinanediol Impurity/(1R)-(1S,2S,3R,5S)-Pinanediol-N-(N-pyrazinylphenylalaninoyl)-1-amino-3-methyl-butane-1-boronate; Bortezomib impurity 98; N-[(1S)-1-benzyl-2-({(1R)-3-methyl-1-[(1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.,6~]dec-4-yl]butyl}amino)-2-oxoethyl]-2-pyrazinecboxamide; (1S,2S,3R,5S)-Pinanediol N-(2-pyrazinecbony1)-L-phenylalanine-L-leucine boronate

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 719.5±60.0 °C at 760 mmHg
• 熔点: 75-83ºC
• 分子式: C₂₉H₃₉BN₄O₄
• 分子量: 518.455
• 闪点: 389.0±32.9 °C
• 精确质量: 518.306458
• PSA: 102.44000
• LogP: 4.81780
• 外观性状: 黄色固体
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.572
• 储存条件: -20°C，保存于惰性气体中

合成路线

98-97-5 ~% 205393-22-2

文献：Journal of Medicinal Chemistry, , vol. 54, # 13 p. 4365 - 4377

13734-34-4 ~% 205393-22-2

文献：Journal of Medicinal Chemistry, , vol. 54, # 13 p. 4365 - 4377

1161-13-3 ~% 205393-22-2

文献：Journal of Medicinal Chemistry, , vol. 54, # 13 p. 4365 - 4377

1187479-72-6 ~% 205393-22-2

文献：Journal of Medicinal Chemistry, , vol. 54, # 13 p. 4365 - 4377

2577-90-4 ~% 205393-22-2

文献：Journal of Medicinal Chemistry, , vol. 54, # 13 p. 4365 - 4377

73058-37-4 ~% 205393-22-2

文献：Journal of Medicinal Chemistry, , vol. 54, # 13 p. 4365 - 4377

7524-50-7 ~% 205393-22-2

文献：WO2012/48745 A1, ;

19847-10-0 789472-91-9 ~% 205393-22-2

文献：Bioorganic and Medicinal Chemistry, , vol. 21, # 4 p. 1018 - 1029

98-97-5 789472-91-9 ~% 205393-22-2

文献：Journal of Medicinal Chemistry, , vol. 54, # 13 p. 4365 - 4377

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