1253-28-7

• 常用中文名：己酸各司孕甾醇
• 常用英文名：Gestonorone Capronate
• CAS号：1253-28-7
• 分子式：C₂₆H₃₈O₄
• 分子量：414.57800
• 相关类别： 原料药 激素及调节内分泌功能类药 雌激素及孕激素类药
• 发布时间：2018-07-24 13:03:54
• 更新时间：2024-01-03 12:18:12
• Gestonorone Capronate是治疗良性前列腺肥大和子宫内膜癌的孕激素。

名称

• 中文名: 己酸各司孕甾醇
• 英文名: gestonorone caproate
• 中文别名: 己酸孕诺酮
• 英文别名: Gestronol hexanoate; Depostat; 17-hexanoyloxy-19-nor-pregn-4-ene-3,20-dione; Primostat; 17-Hexanoyloxy-19-nor-pregn-4-en-3,20-dion; Depostat (TN); Gestronol caproate; ZK 5623; SH 582; Gestonorone Capronate

物化性质

• 密度: 1.11g/cm3
• 沸点: 535.4ºC at 760mmHg
• 熔点: 123-124°
• 分子式: C₂₆H₃₈O₄
• 分子量: 414.57800
• 闪点: 228.4ºC
• 精确质量: 414.27700
• PSA: 60.44000
• LogP: 5.57950
• 蒸汽压: 1.54E-11mmHg at 25°C
• 折射率: 1.534
• 储存条件: -20°C，密闭，干燥

生物活性

• 描述: Gestonorone Capronate是治疗良性前列腺肥大和子宫内膜癌的孕激素。
• 相关类别:
  信号通路 >> 其他 >> 孕激素受体
  研究领域 >> 癌症
• 体外研究: 给予孕二烯酮青蒿素可以减少睾酮的减少。氧化途径仍未受到影响。这种对5α-还原产物形成的抑制作用存在于最低剂量的孕甾酮青蒿酸盐中,随着孕甾酮蛋白酸盐浓度的增加而逐渐增加[1]。
• 参考文献:

  [1]. Orestano F, et al. Mode of action of progesterone, gestonorone capronate (Depostat) and cyproterone acetate (Androcur) on the metabolism of testosterone in human prostatic adenoma: in vitro and in vivo investigations. J Steroid Biochem. 1975 Jun;6(6):845-51.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : RC8960700 CHEMICAL NAME : 19-Norpregn-4-ene-3,20-dione, 17-hydroxy-, hexanoate CAS REGISTRY NUMBER : 1253-28-7 LAST UPDATED : 199210 DATA ITEMS CITED : 13 MOLECULAR FORMULA : C26-H38-O4 MOLECULAR WEIGHT : 414.64 WISWESSER LINE NOTATION : L E5 B666 OV MUTJ E1 FV1 FOV5 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >10 gm/kg TOXIC EFFECTS : Gastrointestinal - other changes REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 8,296,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 6800 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 13,349,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >10 gm/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 8,296,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 400 mg/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - respiratory depression REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 8,296,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >10 gm/kg TOXIC EFFECTS : Liver - other changes REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 8,296,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >10 gm/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Liver - other changes Blood - changes in spleen REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 8,296,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 10 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 13,349,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >150 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 13,349,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3500 mg/kg/28W-I TOXIC EFFECTS : Related to Chronic Data - changes in ovarian weight Related to Chronic Data - changes in prostate weight Related to Chronic Data - changes in testicular weight REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 9,307,1978 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 12 gm/kg/30D-I TOXIC EFFECTS : Liver - changes in liver weight Related to Chronic Data - changes in prostate weight Related to Chronic Data - changes in testicular weight REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 9,275,1978 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2520 mg/kg/28W-I TOXIC EFFECTS : Related to Chronic Data - changes in ovarian weight Related to Chronic Data - changes in prostate weight Related to Chronic Data - changes in testicular weight REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 9,307,1978 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 540 mg/kg/35D-I TOXIC EFFECTS : Liver - changes in liver weight Related to Chronic Data - changes in prostate weight Related to Chronic Data - changes in testicular weight REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 9,275,1978 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 160 mg/kg/30D-I TOXIC EFFECTS : Liver - changes in liver weight Related to Chronic Data - changes in ovarian weight Related to Chronic Data - changes in prostate weight REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 9,275,1978

合成路线

2051-49-2 2137-18-0 ~% 1253-28-7

文献：DE1074582 , ;

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