中文名 | 粪卟啉III二盐酸盐 |
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英文名 | coproporphyrin III |
中文别名 | 酚卟啉二盐酸盐 |
英文别名 |
3,3',3'',3'''-(3,8,13,17-tetramethyl-porphyrin-2,7,12,18-tetrayl)-tetra-propionic acid
COPROPORPHYRIN III DIHYDROCHLORIDE 3,3',3'',3'''-(3,8,13,17-Tetramethyl-porphyrin-2,7,12,18-tetrayl)-tetra-propionsaeure 3,3',3'',3'''-(3,8,13,17-tetramethyl-21H,23H-porphine-2,7,12,18-tetrayl)-tetrakis-propionic acid CoproporphyrinIII Dihyrochloride 2,7,12,18-Tetramethyl-21H,23H-porphyrin-3,8,13,17-tetrapropionic acid coproporphyrin Coproporphyrin III Coproporphyrin dihydrochloride coproporphyriniii2HCl 3,8,13,17-tetramethylporphyrin-2,7,12,18-tetrapropanoic acid 3,8,13,17-TETRAMETHYL-21H,23H-PORPHINE-2,7,12,18-TETRAPROPIONIC ACID DIHYDROCHLORIDE Koproporphyrin III Coproporphyrin III dihydrochloride,3,8,13,17-Tetramethyl-21H,23H-porphine-2,7,12,18-tetrapropionic acid dihydrochloride |
描述 | Coproporphyrin III是卟啉衍生物。 |
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相关类别 | |
靶点 |
Human Endogenous Metabolite |
体外研究 | 从粪便和尿液中大量反复分离粪卟啉III甲酯。粪卟啉III排泄量的大幅增加是伴随着卟啉症,金属或化学中毒或肝脏疾病的症状或体征[1]。鸡胚肝细胞的原代培养物已被用于研究化学物质引起血红素合成途径的中间体积累的机制。在卟啉前体5-氨基乙酰丙酸(ALA)存在下,添加胰岛素导致尿卟啉I和粪卟啉III的累积显着增加。抗氧化剂消除了尿卟啉I的积累并增加了粪卟啉III [2]。 |
体内研究 | 尿DMA和卟啉谱可用作癌症发作前慢性MMA暴露的早期预警生物标志物。 4周后,与对照组相比,所有治疗组的粪卟啉III浓度水平显着增加[3]。 |
参考文献 |
密度 | 1.366 g/cm3 |
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沸点 | 1258ºC at 760 mmHg |
分子式 | C36H38N4O8 |
分子量 | 654.71 |
闪点 | 714.6ºC |
PSA | 205.50000 |
LogP | 4.69760 |
外观性状 | 紫色晶体 |
蒸汽压 | 0mmHg at 25°C |
折射率 | 1.638 |
储存条件 | 2-8℃ |
分子结构 | 五、分子性质数据: 1、 摩尔折射率:172.17 2、 摩尔体积(m3/mol):479.0 3、 等张比容(90.2K):1379.6 4、 表面张力(dyne/cm):68.7 5、 极化率(10-24cm3):68.25 |
计算化学 | 1、 疏水参数计算参考值(XlogP): 2、 氢键供体数量:8 3、 氢键受体数量10 4、 可旋转化学键数量:12 5、 互变异构体数量:6 6、 拓扑分子极性表面积(TPSA):207 7、 重原子数量:50 8、 表面电荷:0 9、 复杂度:1170 10、 同位素原子数量:0 11、 确定原子立构中心数量:0 12、 不确定原子立构中心数量:0 13、 确定化学键立构中心数量:0 14、 不确定化学键立构中心数量:0 15、 共价键单元数量:3 |
更多 | 1.性状:未确定 2.密度(g/mL,25/4℃):未确定 3.相对蒸汽密度(g/mL,空气=1):未确定 4.熔点(ºC):未确定 5.沸点(ºC,常压):未确定 6.沸点(ºC,5.2kPa):未确定 7.折射率:未确定 8.闪点(ºC):未确定 9.比旋光度(º):未确定 10.自燃点或引燃温度(ºC):未确定 11.蒸气压(kPa,25ºC):未确定 12.饱和蒸气压(kPa,60ºC):未确定 13.燃烧热(KJ/mol):未确定 14.临界温度(ºC):未确定 15.临界压力(KPa):未确定 16.油水(辛醇/水)分配系数的对数值:未确定 17.爆炸上限(%,V/V):未确定 18.爆炸下限(%,V/V):未确定 19.溶解性:未确定 |
Section 1: Product Identification Chemical Name:Coproporphyrin III dihydrochloride CAS Registry Number:14643-66-4 Formula:C36H38N4O8.2HCl EINECS Number:none Chemical Family:porphine (porphyrin) ligand Synonym:None
Section 2: Composition and Information on Ingredients IngredientCAS NumberPercentACGIH (TWA)OSHA (PEL) Title Compound14643-66-4100%no datano data Section 3: Hazards Identification Emergency Overview:No particular hazard associated with this material. Primary Routes of Exposure:Ingestion, inhalation Eye Contact:May cause slight to mild irritation of the eyes. Skin Contact:May cause slight to mild irritation of the skin. Inhalation:May be irritating to the nose, mucous membranes and respiratory tract. Ingestion:No specific information is available on the physiological effects of ingestion. Acute Health Affects:May be irritating to skin, eyes and respiratory tract. Chronic Health Affects:No information available on long-term chronic effects. NTP:No IARC:No OSHA:No SECTION 4: First Aid Measures Immediately flush the eyes with copious amounts of water for at least 10-15 minutes. A victim may need Eye Exposure: assistance in keeping their eye lids open. Get immediate medical attention. Wash the affected area with water. Remove contaminated clothes if necessary. Seek medical assistance if Skin Exposure: irritation persists. Remove the victim to fresh air. Closely monitor the victim for signs of respiratory problems, such as difficulty Inhalation: in breathing, coughing, wheezing, or pain. In such cases seek immediate medical assistance. Seek medical attention immediately. Keep the victim calm. Give the victim water (only if conscious). Induce Ingestion: vomiting only if directed by medical personnel. SECTION 5: Fire Fighting Measures Flash Point:no data Autoignition Temperature:none Explosion Limits:none Extinguishing Medium:carbon dioxide, dry powder or foam If this material is involved in a fire, fire fighters should be equipped with a NIOSH approved, positive pressure Special Fire Fighting Procedures: self contained breathing apparatus and full protective clothing. Hazardous Combustion andIf involved in a fire this material may emit toxic organic fumes. Decomposion Products: Unusual Fire or Explosion Hazards: No unusual fire or explosion hazards. SECTION 6: Accidental Release Measures Spill and Leak Procedures:Small spills can be mixed with vermiculite or sodium carbonate and swept up. SECTION 7: Handling and Storage Handling and Storage:Store in a tightly sealed container. Keep away from heat and direct sunlight. SECTION 8: Exposure Controls and Personal Protection Eye Protection:Always wear approved safety glasses when handling a chemical substance in the laboratory. Skin Protection:Wear protective clothing and gloves. Ventilation:Material may form a fine dust. If possible, handle the material in an efficient fume hood. If ventilation is not available a respirator should be worn. The use of respirators requires a Respirator Respirator: Protection Program to be in compliance with 29 CFR 1910.134. Ventilation:Material may form a fine dust. If possible, handle the material in an efficient fume hood. Additional Protection:No additional protection required. SECTION 9: Physical and Chemical Properties Color and Form:purple xtl. Molecular Weight:727.64 Melting Point:no data Boiling Point:no data Vapor Pressure:no data Specific Gravity:no data Odor:none Solubility in Water:soluble SECTION 10: Stability and Reactivity Stability:air and moisture stable solid Hazardous Polymerization:no hazardous polymerization Conditions to Avoid:none Incompatibility:oxidizing agents Decomposition Products:carbon dioxide, carbon monoxide, nitrogen oxides, and organic fumes SECTION 11: Toxicological Information RTECS Data:No information available in the RTECS files. Carcinogenic Effects:No data available Mutagenic Effects:No data available Tetratogenic Effects:No data available SECTION 12: Ecological Information Ecological Information:No information available SECTION 13: Disposal Considerations Disposal:Dispose of according to local, state and federal regulations. SECTION 14: Transportation Shipping Name (CFR):Non-hazardous Hazard Class (CFR):NA Additional Hazard Class (CFR):NA Packaging Group (CFR):NA UN ID Number (CFR):NA Shipping Name (IATA):Non-hazardous Hazard Class (IATA):NA Additional Hazard Class (IATA):NA Packaging Group (IATA):NA UN ID Number (IATA):NA SECTION 15: Regulatory Information TSCA:Not listed in the TSCA inventory. SARA (Title 313):Not reportable under SARA Title 313 Second Ingredient:none SECTION 16 - ADDITIONAL INFORMATION N/A |
~% 14643-66-4 |
文献:Tetrahedron Letters, , vol. 46, # 50 p. 8669 - 8672 |
~% 14643-66-4 |
文献:Tetrahedron Letters, , vol. 46, # 50 p. 8669 - 8672 |
~% 14643-66-4 |
文献:Tetrahedron Letters, , vol. 46, # 50 p. 8669 - 8672 |