| 中文名 | 2-吡啶肟甲磺酸甲酯 |
|---|---|
| 英文名 | pralidoxime mesylate |
| 中文别名 | 吡啶-2-醛肟甲基甲磺酸酯 |
| 英文别名 |
protopammethanesulfonate
pralidoximemethosulfate 2-(hydroxyimino-methyl)-1-methyl-pyridinium,methanesulfonate contrathion pralidoxime mesilate pralidoxime methanesulphonate pralidoximemesylate Pralidoxime methylsulfate 2-(Hydroxyimino-methyl)-1-methyl-pyridinium,Methansulfonat 2-PYRIDINEALDOXIME METHYL METHANESULFONATE Pralidoxime p2s pyridine-2-aldoxime methyl methanesulfonate Einecs 205-839-8 2-pammethanesulfonate |
| 沸点 | 189.7ºC at 760mmHg |
|---|---|
| 分子式 | C8H12N2O4S |
| 分子量 | 232.25700 |
| 闪点 | 68.5ºC |
| 精确质量 | 232.05200 |
| PSA | 102.05000 |
| LogP | 0.56140 |
| 储存条件 | 2-8℃。 |
| 计算化学 | 1.疏水参数计算参考值（XlogP）:无 2.氢键供体数量:1 3.氢键受体数量:5 4.可旋转化学键数量:1 5.互变异构体数量:无 6.拓扑分子极性表面积99.9 7.重原子数量:15 8.表面电荷:0 9.复杂度:295 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:1 14.不确定化学键立构中心数量:0 15.共价键单元数量:2 |
|
Date Updated: 11/FEB/2006
Version 1.2 Regulation (EC) No 1907/2006 ________________________________________________________________________ 1 - Product and Company Information ________________________________________________________________________ Product NamePYRIDINE-2-ALDOXIME METHYL
METHANESULFONATE Product NumberP0268 Company Century Ba-Shi Building 22A-B, 200020 Shanghai Technical Phone #86-21-61415566 Fax 86-21-61415567 E-mail Address ________________________________________________________________________ 2 - Hazards Identification ________________________________________________________________________ ________________________________________________________________________ 3 - Composition/Information on Ingredients ________________________________________________________________________ Product NameCAS #EC noAnnex I Index Number 2-PYRIDINEALDOXIME METHYL154-97-2 205-839-8 None METHANE-SULFONATE, 95% FormulaC7H9N2O.CH3O3S Molecular Weight 232,2600 AMU SynonymsContrathion * 2-Formyl-N-methylpyridinium oxime methanesulfonat * 2-Formyl-1-methylpyridinium methanesulfonate oxim * 2-Hydroxyiminomethyl-N-methylpyridinium methanesulphonate * N-Methylpyridinium-2-aldoxime methanesulphonate * 1-Methylpyridinium-2-aldoxime methanesulfonate * N-Methylpyridinium methane sulfonate 2-aldoxime * 2-Pam methanesulfonate * Pralidoxime mesylate * Pralidoxime methanesulfonate * Pralidoxime methosulfate * Protopam methanesulfonate * P2S * Pyridinium, 2-aldoxime, N-methyl methanesulphonat * Pyridinium, 2-((hydroxyimino)methyl)-1-methyl-, methanesulfonate (salt) (9CI) ________________________________________________________________________ 4 - First Aid Measures ________________________________________________________________________ AFTER INHALATION If inhaled, remove to fresh air. If breathing becomes difficult, call a physician. AFTER SKIN CONTACT In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician. AFTER EYE CONTACT In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician. AFTER INGESTION If swallowed, wash out mouth with water provided person is conscious. Call a physician. ________________________________________________________________________ 5 - Fire Fighting Measures ________________________________________________________________________ EXTINGUISHING MEDIA Suitable: Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. SPECIAL RISKS Specific Hazard(s): Emits toxic fumes under fire conditions. SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes. ________________________________________________________________________ 6 - Accidental Release Measures ________________________________________________________________________ PROCEDURE(S) OF PERSONAL PRECAUTION(S) Wear protective equipment. METHODS FOR CLEANING UP Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete. ________________________________________________________________________ 7 - Handling and Storage ________________________________________________________________________ STORAGE Store at 2-8°C ________________________________________________________________________ 8 - Exposure Controls / Personal Protection ________________________________________________________________________ ENGINEERING CONTROLS Mechanical exhaust required. PERSONAL PROTECTIVE EQUIPMENT Special Protective Measures: Wear appropriate government approved respirator, chemical-resistant gloves, safety goggles, other protective clothing. ________________________________________________________________________ 9 - Physical and Chemical Properties ________________________________________________________________________ pH N/A BP/BP RangeN/A MP/MP Range154,000. - 156,000 ° C. Flash PointN/A FlammabilityN/A Autoignition TempN/A Oxidizing Properties N/A Explosive Properties N/A Explosion LimitsN/A Vapor PressureN/A Partition Coefficient N/A ViscosityN/A Vapor DensityN/A Saturated Vapor Conc. N/A Evaporation RateN/A Bulk DensityN/A Decomposition Temp.N/A Solvent ContentN/A Water ContentN/A Surface TensionN/A ConductivityN/A Miscellaneous DataN/A SolubilityN/A ________________________________________________________________________ 10 - Stability and Reactivity ________________________________________________________________________ STABILITY Stable: Stable. HAZARDOUS DECOMPOSITION PRODUCTS Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide, Nitrogen oxides, Sulfur oxides. HAZARDOUS POLYMERIZATION Hazardous Polymerization: Will not occur ________________________________________________________________________ 11 - Toxicological Information ________________________________________________________________________ RTECS NUMBER: UU4570000 ACUTE TOXICITY LD50 Oral Rat 7000,000000 mg/kg LD50 Intraperitoneal Rat 262 MG/KG Remarks: Lungs, Thorax, or Respiration:Dyspnea. Behavioral:Convulsions or effect on seizure threshold. Behavioral:Tremor. LD50 Subcutaneous Rat 332 MG/KG Remarks: Lungs, Thorax, or Respiration:Dyspnea. Behavioral:Convulsions or effect on seizure threshold. Behavioral:Tremor. LD50 Intravenous Rat 109 MG/KG Remarks: Lungs, Thorax, or Respiration:Dyspnea. Behavioral:Convulsions or effect on seizure threshold. Behavioral:Tremor. LD50 Oral Mouse 3700,000000 mg/kg LD50 Intraperitoneal Mouse 132 MG/KG LD50 Subcutaneous Mouse 165 MG/KG Remarks: Lungs, Thorax, or Respiration:Dyspnea. Behavioral:Convulsions or effect on seizure threshold. Behavioral:Tremor. LD50 Intravenous Mouse 118 MG/KG LD50 Intramuscular Monkey 356 MG/KG Remarks: Behavioral:Tremor. Behavioral:Convulsions or effect on seizure threshold. Lungs, Thorax, or Respiration:Dyspnea. LD50 Intravenous Rabbit 118 MG/KG Remarks: Behavioral:Convulsions or effect on seizure threshold. Behavioral:Muscle weakness. Lungs, Thorax, or Respiration:Cyanosis. LD50 Intramuscular Rabbit 258 MG/KG Remarks: Behavioral:Convulsions or effect on seizure threshold. Behavioral:Muscle weakness. Lungs, Thorax, or Respiration:Cyanosis. ROUTE OF EXPOSURE Multiple Routes: May cause irritation. May be harmful by inhalation, ingestion, or skin absorption. CONDITIONS AGGRAVATED BY EXPOSURE The toxicological properties have not been thoroughly investigated. ________________________________________________________________________ 12 - Ecological Information ________________________________________________________________________ No data available. ________________________________________________________________________ 13 - Disposal Considerations ________________________________________________________________________ SUBSTANCE DISPOSAL Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Observe all federal, state, and local environmental regulations. ________________________________________________________________________ 14 - Transport Information ________________________________________________________________________ RID/ADR Non-hazardous for road transport. IMDG Non-hazardous for sea transport. IATA Non-hazardous for air transport. ________________________________________________________________________ 15 - Regulatory Information ________________________________________________________________________ COUNTRY SPECIFIC INFORMATION Germany WGK: 2 Self-Classification ________________________________________________________________________ 16 - Other Information ________________________________________________________________________ WARRANTY The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any shall not be held liable for any damage resulting from handling or from contact with the above product. See reverse side of invoice or packing slip for additional terms and conditions of sale. unlimitedpaper copies for internal use only. DISCLAIMER For R&D use only. Not for drug, household or other uses. 模块 15 - 法规信息 N/A 模块16 - 其他信息 N/A |
|
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
|
~88%
154-97-2 |
| 文献：Unnisa, Lateef; Sumakanth; Rao, B. Leelamaheswara; Divi, Murali Krishnaprasad; Rao, Mysore Aswathanarayana Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2014 , vol. 53, # 4 p. 431 - 435 |
|
~%
154-97-2 |
| 文献：Journal of Pharmacy and Pharmacology, , vol. 11, p. 485 Biochemical Journal, , vol. 72, p. 70 |
