77469-44-4

• 常用中文名：1-(2-chloroethyl)-3-[2-[2-[(2-chloroethyl-nitroso-carbamoyl)amino]ethy ldisulfanyl]ethyl]-1-nitroso-urea
• 常用英文名：1-(2-chloroethyl)-3-[2-[2-[(2-chloroethyl-nitroso-carbamoyl)amino]ethy ldisulfanyl]ethyl]-1-nitroso-urea
• CAS号：77469-44-4
• 分子式：C₁₀H₁₈Cl₂N₆O₄S₂
• 分子量：421.32400
• 发布时间：2017-05-19 19:20:48
• 更新时间：2025-11-25 12:05:34

名称

• 英文名: 1-(2-chloroethyl)-3-[2-[2-[[2-chloroethyl(nitroso)carbamoyl]amino]ethyldisulfanyl]ethyl]-1-nitrosourea
• 英文别名: Ditiomustine; CNCC; I.C.I.G. 1325

物化性质

• 分子式: C₁₀H₁₈Cl₂N₆O₄S₂
• 分子量: 421.32400
• 精确质量: 420.02100
• PSA: 201.14000
• LogP: 2.57780
• 储存条件: 库房通风低温干燥,与食品原料分开存放

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : YT2150000 CHEMICAL NAME : Urea, 1,1'-dithiodiethylenebis(3-(2-chloroethyl)-3-nitroso- CAS REGISTRY NUMBER : 77469-44-4 LAST UPDATED : 199612 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C10-H18-Cl2-N6-O4-S2 MOLECULAR WEIGHT : 421.36 WISWESSER LINE NOTATION : ONNG2&VM2SS2MVNNO&2G HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 280 mg/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 75 mg/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent MUTATION DATA TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Rodent - mouse Cells - not otherwise specified DOSE/DURATION : 20 mg/L REFERENCE : INSSDM INSERM Symposium. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) No.1- 1975- Volume(issue)/page/year: 19,229,1981

合成路线

80354-51-4 56-17-7 ~73% 77469-44-4

文献：Martinez, Jean; Oiry, Joel; Imbach, Jean Louis; Winternitz, Francois Journal of Medicinal Chemistry, 1982 , vol. 25, # 2 p. 178 - 182

56-17-7 80354-53-6 ~75% 77469-44-4

文献：Martinez, Jean; Oiry, Joel; Imbach, Jean Louis; Winternitz, Francois Journal of Medicinal Chemistry, 1982 , vol. 25, # 2 p. 178 - 182

56-17-7 80354-49-0 ~75% 77469-44-4

文献：Martinez, Jean; Oiry, Joel; Imbach, Jean Louis; Winternitz, Francois Journal of Medicinal Chemistry, 1982 , vol. 25, # 2 p. 178 - 182

56-17-7 80354-55-8 ~76% 77469-44-4

文献：Martinez, Jean; Oiry, Joel; Imbach, Jean Louis; Winternitz, Francois Journal of Medicinal Chemistry, 1982 , vol. 25, # 2 p. 178 - 182

90213-05-1 ~% 77469-44-4

文献：Oiry; Pompon; Madelmont; Imbach European Journal of Medicinal Chemistry, 1984 , vol. 19, # 4 p. 311 - 314

77456-13-4 ~% 77469-44-4 77456-14-5 90213-04-0

文献：Oiry; Imbach European Journal of Medicinal Chemistry, 1984 , vol. 19, # 4 p. 305 - 309