76458-47-4

• 常用中文名：3H-1,4-BENZODIAZEPIN-3-OL, 7-CHLORO-2-(DIMETHYLAMINO)-5-PHENYL-
• 常用英文名：3H-1,4-BENZODIAZEPIN-3-OL, 7-CHLORO-2-(DIMETHYLAMINO)-5-PHENYL-
• CAS号：76458-47-4
• 分子式：C₁₇H₁₆ClN₃O
• 分子量：313.78100
• 发布时间：2016-08-26 13:29:34
• 更新时间：2025-10-04 05:51:35

名称

• 英文名: 7-chloro-2-(dimethylamino)-5-phenyl-3H-1,4-benzodiazepin-3-ol
• 英文别名: 7-Chloro-2-dimethylamino-3-hydroxy-5-phenyl-3H-1,4-benzodiazepine; 3H-1,4-BENZODIAZEPIN-3-OL,7-CHLORO-2-(DIMETHYLAMINO)-5-PHENYL

物化性质

• 密度: 1.27g/cm3
• 沸点: 479.4ºC at 760 mmHg
• 分子式: C₁₇H₁₆ClN₃O
• 分子量: 313.78100
• 闪点: 243.7ºC
• 精确质量: 313.09800
• PSA: 48.19000
• LogP: 1.97220
• 折射率: 1.638

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DE9735000 CHEMICAL NAME : 3H-1,4-Benzodiazepin-3-ol, 7-chloro-2-(dimethylamino)-5-phenyl- CAS REGISTRY NUMBER : 76458-47-4 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C17-H16-Cl-N3-O MOLECULAR WEIGHT : 313.81 WISWESSER LINE NOTATION : T67 GN JN HHJ CG HN1&1 IQ KR HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 250 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Behavioral - muscle weakness REFERENCE : FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 37,343,1982

合成路线

76458-41-8 ~85% 76458-47-4

文献：Gatta; Del Giudice; Di Simone; Settimj Journal of Heterocyclic Chemistry, 1980 , vol. 17, # 5 p. 865 - 868

3693-14-9 ~% 76458-47-4

文献：Gatta; Del Giudice; Di Simone; Settimj Journal of Heterocyclic Chemistry, 1980 , vol. 17, # 5 p. 865 - 868

82212-32-6 ~% 76458-47-4

文献：Del Giudice; Gatta; Pandolfi; Settimj Farmaco, Edizione Scientifica, 1982 , vol. 37, # 5 p. 343 - 352

1824-74-4 ~% 76458-47-4

文献：Del Giudice; Gatta; Pandolfi; Settimj Farmaco, Edizione Scientifica, 1982 , vol. 37, # 5 p. 343 - 352

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