37795-69-0

• 常用中文名：W-2429
• 常用英文名：W-2429
• CAS号：37795-69-0
• 分子式：C₁₀H₈N₂O₂
• 分子量：188.18300
• 相关类别： 研究领域 神经疾病
• 发布时间：2017-10-22 18:26:38
• 更新时间：2024-02-04 22:29:38
• W-2429 是一种非麻醉性镇痛药。

名称

• 中文名: W-2429
• 英文名: 2,3-dihydro-[1,2]oxazolo[3,2-b]quinazolin-9-one
• 英文别名: W 2429; 2,3-dihydro-9H-isoxazolo<3,2-b>quinazolin-9-one; W-2429

物化性质

• 密度: 1.47g/cm3
• 沸点: 330ºC at 760mmHg
• 分子式: C₁₀H₈N₂O₂
• 分子量: 188.18300
• 闪点: 153.4ºC
• 精确质量: 188.05900
• PSA: 44.12000
• LogP: 0.38120
• 折射率: 1.719
• 储存条件: 2-8℃

生物活性

• 描述: W-2429 是一种非麻醉性镇痛药。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 体内研究: W-2429是一种非麻醉性镇痛剂。大鼠以及狗对W-2429的治疗耐受良好。在狗中,观察到的唯一毒性迹象是在100mg/kg /天W-2429下食欲和流涎减少。没有观察到其他物理,化学,严重或组织病理学变化的重要证据[1]。
• 参考文献:

  [1]. Banerjee BN, et al. Toxicological investigation of 2,3-dihydro-9H-isoxazolo[3,2-b]quinazolin-9-one (W-2429). Acuteand subacute toxicity in mice, rats and dogs. Arzneimittelforschung. 1977;27(4):793-801.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NY3450000 CHEMICAL NAME : 9H-Isoxazolo(3,2-b)quinazolin-9-one, 2,3-dihydro- CAS REGISTRY NUMBER : 37795-69-0 LAST UPDATED : 199706 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C10-H8-N2-O2 MOLECULAR WEIGHT : 188.20 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 395 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - ataxia Behavioral - convulsions or effect on seizure threshold REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,770,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 278 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - ataxia Behavioral - convulsions or effect on seizure threshold REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,770,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 420 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - ataxia Behavioral - convulsions or effect on seizure threshold REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,770,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 212 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - ataxia Behavioral - convulsions or effect on seizure threshold REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,770,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 700 mg/kg TOXIC EFFECTS : Behavioral - food intake (animal) Gastrointestinal - changes in structure or function of salivary glands REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,793,1977 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3 gm/kg/30D-C TOXIC EFFECTS : Brain and Coverings - changes in brain weight Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,793,1977 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 3 gm/kg/30D-I TOXIC EFFECTS : Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,793,1977

安全

• 海关编码: 2934999090

合成路线

37795-76-9 ~% 37795-69-0

文献：Reisner; Ludwig; Simon; Dejneka; Sofia Arzneimittel-Forschung/Drug Research, 1977 , vol. 27, # 4 p. 766 - 770

134-20-3 ~% 37795-69-0

文献：Reisner; Ludwig; Simon; Dejneka; Sofia Arzneimittel-Forschung/Drug Research, 1977 , vol. 27, # 4 p. 766 - 770

118-48-9 625-36-5 ~% 37795-69-0

文献：Dunn, A. D.; Kinnear, K. I.; Norrie, R.; Ringan, N.; Martin, D. Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 175 - 180

1192-07-0 118-48-9 ~% 37795-69-0

文献：Reisner; Ludwig; Simon; Dejneka; Sofia Arzneimittel-Forschung/Drug Research, 1977 , vol. 27, # 4 p. 766 - 770

上下游产品

上游产品  5
37795-76-9 134-20-3 118-48-9 625-36-5
1192-07-0
下游产品  1
63480-08-0

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%