50-19-1

• 常用中文名：奥芬氨酯
• 常用英文名：Oxyfenamate
• CAS号：50-19-1
• 分子式：C₁₁H₁₅NO₃
• 分子量：209.24200
• 相关类别： 研究领域 神经疾病
• 发布时间：2018-02-26 08:00:00
• 更新时间：2025-08-24 23:54:31
• Oxyfenamate 是一种抗焦虑药。

名称

• 中文名: 奥芬氨酯
• 英文名: (2-hydroxy-2-phenylbutyl) carbamate
• 英文别名: 2-Hydroxy-2-phenylbutyl-carbamat; Phenylbutamate; Hydroxyphenamate; Listica; Oxifenamatum; oxyfenamate; Hidroxifenamato; Tensifen; AL-0361; Oxyphenamate; Oxifenamate; Hydroxyphenamat

物化性质

• 密度: 1.18g/cm3
• 沸点: 415.4ºC at 760 mmHg
• 分子式: C₁₁H₁₅NO₃
• 分子量: 209.24200
• 闪点: 205.1ºC
• 精确质量: 209.10500
• PSA: 72.55000
• LogP: 2.07980
• 折射率: 1.545
• 储存条件: 2-8℃
• 计算化学:

  1.疏水参数计算参考值（XlogP）:1.1

  2.氢键供体数量:2

  3.氢键受体数量:3

  4.可旋转化学键数量:5

  5.互变异构体数量:2

  6.拓扑分子极性表面积:72.6

  7.重原子数量:15

  8.表面电荷:0

  9.复杂度:214

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:1

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

生物活性

• 描述: Oxyfenamate 是一种抗焦虑药。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : EK2450000 CHEMICAL NAME : 1,2-Butanediol, 2-phenyl-, 1-carbamate CAS REGISTRY NUMBER : 50-19-1 LAST UPDATED : 199612 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C11-H15-N-O3 MOLECULAR WEIGHT : 209.27 WISWESSER LINE NOTATION : ZVO1XQ2&R HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 607 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,394,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 830 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DNSSAW Diseases of the Nervous System, Supplement. (Irvington, NJ) For publisher information, see DNSYAG. Volume(issue)/page/year: 22,9,1961 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 425 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DNSSAW Diseases of the Nervous System, Supplement. (Irvington, NJ) For publisher information, see DNSYAG. Volume(issue)/page/year: 22,9,1961 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 233 gm/kg/52W-I TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Related to Chronic Data - death REFERENCE : DNSSAW Diseases of the Nervous System, Supplement. (Irvington, NJ) For publisher information, see DNSYAG. Volume(issue)/page/year: 22,9,1961

安全

• 海关编码: 2924299090

海关

海关编码	2924299090
中文概述	2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 包装
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%