58349-23-8

• 常用中文名：(S)-5-甲氧基-1,2,3,4-四氢-N-(苯甲基)-2-萘胺
• 常用英文名：(S)-5-methoxy-1,2,3,4-tetrahydro-N-(phenylmethyl)- 2-Naphthalenamine (Rotigotine)
• CAS号：58349-23-8
• 分子式：C₁₈H₂₁NO
• 分子量：267.365
• 相关类别： 医药中间体 原料药中间体
• 发布时间：2018-12-05 11:53:57
• 更新时间：2025-08-25 10:40:00

名称

• 中文名: (S)-5-甲氧基-1,2,3,4-四氢-N-(苯甲基)-2-萘胺
• 英文名: (S)-5-methoxy-1,2,3,4-tetrahydro-N-(phenylmethyl)- 2-Naphthalenamine (Rotigotine)
• 英文别名: N-benzyl-N-[(2S)-5-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl]amine; (2S)-N-Benzyl-5-methoxy-1,2,3,4-tetrahydro-2-naphthalenamine; (2S)-N-Benzyl-5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine; 2-Naphthalenamine, 1,2,3,4-tetrahydro-5-methoxy-N-(phenylmethyl)-, (2S)-; (S)-5-Methoxy-1,2,3,4-tetrahydro-N-(phenylmethyl)-2-naphthalenamine; (S)-5-methoxy-1,2,3,4-tetrahydro-N-(phenylmethyl)-2-Naphthalenamine(Rotigotine); (-)-2-(benzylamino)-5-methoxytetralin; (S)-(-)-2-(N-benzylamino)-5-methoxytetralin

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 424.4±45.0 °C at 760 mmHg
• 分子式: C₁₈H₂₁NO
• 分子量: 267.365
• 闪点: 176.6±18.2 °C
• 精确质量: 267.162323
• PSA: 21.26000
• LogP: 4.07
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.594

安全

• 海关编码: 2922299090

合成路线

58349-24-9 ~% 58349-23-8

文献：Laboratorios del Dr. Esteve S.A. Patent: EP1956006 A1, 2008 ; Location in patent: Page/Page column 27 ; EP 1956006 A1

32940-15-1 ~% 58349-23-8

文献：Bakthavachalam, Venkatesalu; Baindur, Nandkishore; Madras, Bertha K.; Neumeyer, John L. Journal of Medicinal Chemistry, 1991 , vol. 34, # 11 p. 3235 - 3241

100-46-9 ~% 58349-23-8

文献：Bakthavachalam, Venkatesalu; Baindur, Nandkishore; Madras, Bertha K.; Neumeyer, John L. Journal of Medicinal Chemistry, 1991 , vol. 34, # 11 p. 3235 - 3241

136247-07-9 ~% 58349-23-8

文献：Bakthavachalam, Venkatesalu; Baindur, Nandkishore; Madras, Bertha K.; Neumeyer, John L. Journal of Medicinal Chemistry, 1991 , vol. 34, # 11 p. 3235 - 3241

海关

海关编码	2922299090
中文概述	2922299090. 其他氨基(萘酚、酚)及醚、酯〔包括它们的盐, 但含有一种以上含氧基的除外〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
Summary	2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%