630423-36-8

• 常用中文名：1,7-二氯-4-甲氧基异喹啉
• 常用英文名：1,7-dichloro-4-methoxyisoquinoline
• CAS号：630423-36-8
• 分子式：C₁₀H₇Cl₂NO
• 分子量：228.075
• 发布时间：2018-09-04 18:48:08
• 更新时间：2025-08-24 16:09:17

名称

• 中文名: 阿那匹韦中间体2
• 英文名: 1,7-dichloro-4-methoxyisoquinoline
• 英文别名: 1,7-dichloro-4-methoxy-isoquinoline; Isoquinoline, 1,7-dichloro-4-methoxy-; ISOQUINOLINE,1,7-DICHLORO-4-METHOXY; 1,7-Dichloro-4-methoxyisoquinoline

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 355.7±37.0 °C at 760 mmHg
• 熔点: 139 °C
• 分子式: C₁₀H₇Cl₂NO
• 分子量: 228.075
• 闪点: 168.9±26.5 °C
• 精确质量: 226.990463
• PSA: 22.12000
• LogP: 3.84
• 外观性状: 固体;White to Yellow to Orange powder to crystal
• 蒸汽压: 0.0±0.8 mmHg at 25°C
• 折射率: 1.631
• 储存条件: 室温

合成路线

67-56-1 1028252-14-3 ~64% 630423-36-8

文献：Scola, Paul M.; Sun, Li-Qiang; Wang, Alan Xiangdong; Chen, Jie; Sin, Ny; Venables, Brian L.; Sit, Sing-Yuen; Chen, Yan; Cocuzza, Anthony; Bilder, Donna M.; D'Andrea, Stanley V.; Zheng, Barbara; Hewawasam, Piyasena; Tu, Yong; Friborg, Jacques; Falk, Paul; Hernandez, Dennis; Levine, Steven; Chen, Chaoqun; Yu, Fei; Sheaffer, Amy K.; Zhai, Guangzhi; Barry, Diana; Knipe, Jay O.; Han, Yong-Hae; Schartman, Richard; Donoso, Maria; Mosure, Kathy; Sinz, Michael W.; Zvyaga, Tatyana; Good, Andrew C.; Rajamani, Ramkumar; Kish, Kevin; Tredup, Jeffrey; Klei, Herbert E.; Gao, Qi; Mueller, Luciano; Colonno, Richard J.; Grasela, Dennis M.; Adams, Stephen P.; Loy, James; Levesque, Paul C.; Sun, Huabin; Shi, Hong; Sun, Lucy; Warner, William; Li, Danshi; Zhu, Jialong; Meanwell, Nicholas A.; McPhee, Fiona Journal of Medicinal Chemistry, 2014 , vol. 57, # 5 p. 1730 - 1752

630423-35-7 ~87% 630423-36-8

文献：Bristol-Myers Squibb Company Patent: US2010/56792 A1, 2010 ; Location in patent: Page/Page column 7-8 ;

1028252-14-3 18107-18-1 ~% 630423-36-8

文献：Bristol-Myers Squibb Company Patent: US2009/274652 A1, 2009 ; Location in patent: Page/Page column 36-37 ; US 20090274652 A1

1028252-14-3 74-88-4 ~97% 630423-36-8

文献：Scola, Paul M.; Sun, Li-Qiang; Wang, Alan Xiangdong; Chen, Jie; Sin, Ny; Venables, Brian L.; Sit, Sing-Yuen; Chen, Yan; Cocuzza, Anthony; Bilder, Donna M.; D'Andrea, Stanley V.; Zheng, Barbara; Hewawasam, Piyasena; Tu, Yong; Friborg, Jacques; Falk, Paul; Hernandez, Dennis; Levine, Steven; Chen, Chaoqun; Yu, Fei; Sheaffer, Amy K.; Zhai, Guangzhi; Barry, Diana; Knipe, Jay O.; Han, Yong-Hae; Schartman, Richard; Donoso, Maria; Mosure, Kathy; Sinz, Michael W.; Zvyaga, Tatyana; Good, Andrew C.; Rajamani, Ramkumar; Kish, Kevin; Tredup, Jeffrey; Klei, Herbert E.; Gao, Qi; Mueller, Luciano; Colonno, Richard J.; Grasela, Dennis M.; Adams, Stephen P.; Loy, James; Levesque, Paul C.; Sun, Huabin; Shi, Hong; Sun, Lucy; Warner, William; Li, Danshi; Zhu, Jialong; Meanwell, Nicholas A.; McPhee, Fiona Journal of Medicinal Chemistry, 2014 , vol. 57, # 5 p. 1730 - 1752

953421-74-4 ~% 630423-36-8

文献：BRISTOL-MYERS SQUIBB COMPANY; SUN, Li-Qiang; SCOLA, Paul Michael Patent: WO2012/166459 A1, 2012 ; WO 2012/166459 A1

1615-02-7 ~% 630423-36-8

文献：Scola, Paul M.; Sun, Li-Qiang; Wang, Alan Xiangdong; Chen, Jie; Sin, Ny; Venables, Brian L.; Sit, Sing-Yuen; Chen, Yan; Cocuzza, Anthony; Bilder, Donna M.; D'Andrea, Stanley V.; Zheng, Barbara; Hewawasam, Piyasena; Tu, Yong; Friborg, Jacques; Falk, Paul; Hernandez, Dennis; Levine, Steven; Chen, Chaoqun; Yu, Fei; Sheaffer, Amy K.; Zhai, Guangzhi; Barry, Diana; Knipe, Jay O.; Han, Yong-Hae; Schartman, Richard; Donoso, Maria; Mosure, Kathy; Sinz, Michael W.; Zvyaga, Tatyana; Good, Andrew C.; Rajamani, Ramkumar; Kish, Kevin; Tredup, Jeffrey; Klei, Herbert E.; Gao, Qi; Mueller, Luciano; Colonno, Richard J.; Grasela, Dennis M.; Adams, Stephen P.; Loy, James; Levesque, Paul C.; Sun, Huabin; Shi, Hong; Sun, Lucy; Warner, William; Li, Danshi; Zhu, Jialong; Meanwell, Nicholas A.; McPhee, Fiona Journal of Medicinal Chemistry, 2014 , vol. 57, # 5 p. 1730 - 1752

24188-74-7 ~% 630423-36-8

文献：Scola, Paul M.; Sun, Li-Qiang; Wang, Alan Xiangdong; Chen, Jie; Sin, Ny; Venables, Brian L.; Sit, Sing-Yuen; Chen, Yan; Cocuzza, Anthony; Bilder, Donna M.; D'Andrea, Stanley V.; Zheng, Barbara; Hewawasam, Piyasena; Tu, Yong; Friborg, Jacques; Falk, Paul; Hernandez, Dennis; Levine, Steven; Chen, Chaoqun; Yu, Fei; Sheaffer, Amy K.; Zhai, Guangzhi; Barry, Diana; Knipe, Jay O.; Han, Yong-Hae; Schartman, Richard; Donoso, Maria; Mosure, Kathy; Sinz, Michael W.; Zvyaga, Tatyana; Good, Andrew C.; Rajamani, Ramkumar; Kish, Kevin; Tredup, Jeffrey; Klei, Herbert E.; Gao, Qi; Mueller, Luciano; Colonno, Richard J.; Grasela, Dennis M.; Adams, Stephen P.; Loy, James; Levesque, Paul C.; Sun, Huabin; Shi, Hong; Sun, Lucy; Warner, William; Li, Danshi; Zhu, Jialong; Meanwell, Nicholas A.; McPhee, Fiona Journal of Medicinal Chemistry, 2014 , vol. 57, # 5 p. 1730 - 1752

1028252-13-2 ~% 630423-36-8

文献：Scola, Paul M.; Sun, Li-Qiang; Wang, Alan Xiangdong; Chen, Jie; Sin, Ny; Venables, Brian L.; Sit, Sing-Yuen; Chen, Yan; Cocuzza, Anthony; Bilder, Donna M.; D'Andrea, Stanley V.; Zheng, Barbara; Hewawasam, Piyasena; Tu, Yong; Friborg, Jacques; Falk, Paul; Hernandez, Dennis; Levine, Steven; Chen, Chaoqun; Yu, Fei; Sheaffer, Amy K.; Zhai, Guangzhi; Barry, Diana; Knipe, Jay O.; Han, Yong-Hae; Schartman, Richard; Donoso, Maria; Mosure, Kathy; Sinz, Michael W.; Zvyaga, Tatyana; Good, Andrew C.; Rajamani, Ramkumar; Kish, Kevin; Tredup, Jeffrey; Klei, Herbert E.; Gao, Qi; Mueller, Luciano; Colonno, Richard J.; Grasela, Dennis M.; Adams, Stephen P.; Loy, James; Levesque, Paul C.; Sun, Huabin; Shi, Hong; Sun, Lucy; Warner, William; Li, Danshi; Zhu, Jialong; Meanwell, Nicholas A.; McPhee, Fiona Journal of Medicinal Chemistry, 2014 , vol. 57, # 5 p. 1730 - 1752

26386-88-9 ~% 630423-36-8

文献：BRISTOL-MYERS SQUIBB COMPANY; SUN, Li-Qiang; SCOLA, Paul Michael Patent: WO2012/166459 A1, 2012 ; WO 2012/166459 A1