5623-18-7

• 常用中文名：甲氨蝶呤杂质D
• 常用英文名：N10-Methyl Pteroic Acid
• CAS号：5623-18-7
• 分子式：C₁₅H₁₄N₆O₃
• 分子量：326.31000
• 相关类别： 分析化学 标准品 药典标准品和杂志标准品
• 发布时间：2016-12-19 20:28:38
• 更新时间：2024-01-11 14:29:31

名称

• 中文名: 甲氨蝶呤杂质D
• 英文名: N10-Methyl Pteroic Acid
• 中文别名: 4-[甲基[(2-氨基-4-羟基蝶啶)-6-基甲基]氨基]苯甲酸
• 英文别名: 4-[(2-amino-4-oxo-1H-pteridin-6-yl)methyl-methylamino]benzoic acid; 4-[Methyl[(2-Amino-4-Hydroxypteridine)-6-Ylmethyl]Amino]Benzoic Acid; Methotrexate Impurity 4

物化性质

• 密度: 1.58g/cm3
• 沸点: 668.3ºC at 760 mmHg
• 分子式: C₁₅H₁₄N₆O₃
• 分子量: 326.31000
• 闪点: 357.9ºC
• 精确质量: 326.11300
• PSA: 138.09000
• LogP: 1.21110
• 折射率: 1.757

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DG2800000 CHEMICAL NAME : Benzoic acid, p-((N-(2-amino-4-hydroxy)pteridin-6-ylmethyl)-N-methy lamino)- CAS REGISTRY NUMBER : 5623-18-7 BEILSTEIN REFERENCE NO. : 0338741 LAST UPDATED : 199712 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C15-H14-N6-O3 MOLECULAR WEIGHT : 326.35 WISWESSER LINE NOTATION : T66 BN DN GN JNJ CZ EQ H1N1&R BVQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Parenteral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 800 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 7,686,1955

合成路线

150-13-0 ~% 5623-18-7

文献：Cosulich; Smith Journal of the American Chemical Society, 1948 , vol. 70, p. 1922,1925

1004-75-7 5221-17-0 10541-83-0 ~% 5623-18-7

文献：Cosulich; Smith Journal of the American Chemical Society, 1948 , vol. 70, p. 1922,1925

19741-14-1 ~% 5623-18-7

文献：Am.Cyanamid Co. Patent: US2525150 , 1949 ;

上下游产品

上游产品  5
150-13-0 1004-75-7 5221-17-0 10541-83-0
19741-14-1
下游产品  0