185039-48-9

• 常用中文名：6-(2,6-二氯苯基)-8-甲基-2-(甲基磺酰基)吡啶并[2,3-d]嘧啶-7(8H)-酮
• 常用英文名：6-(2,6-Dichlorophenyl)-8-methyl-2-methylsulfonyl-8H-pyrido[2,3-d]pyrimidin-7-one
• CAS号：185039-48-9
• 分子式：C₁₅H₁₁Cl₂N₃O₃S
• 分子量：384.237
• 发布时间：2018-12-26 09:34:27
• 更新时间：2025-09-21 11:43:13

名称

• 中文名: 6-(2,6-二氯苯基)-8-甲基-2-甲基磺酰基-8H-吡啶并[2,3-d]嘧啶-7-酮
• 英文名: 6-(2,6-Dichlorophenyl)-8-methyl-2-methylsulfonyl-8H-pyrido[2,3-d]pyrimidin-7-one
• 中文别名: 6-(2,6-二氯苯基)-8-甲基-2-甲基磺酰基-8H-吡啶并[2,3-D]嘧啶-7-酮
• 英文别名: Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(2,6-dichlorophenyl)-8-methyl-2-(methylsulfonyl)-; 6-(2,6-Dichlorophenyl)-8-methyl-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one; 6-(2,6-dichlorophenyl)-8-methyl-2-methylsulfonylpyrido[2,3-d]pyrimidin-7-one

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 588.4±60.0 °C at 760 mmHg
• 分子式: C₁₅H₁₁Cl₂N₃O₃S
• 分子量: 384.237
• 闪点: 309.7±32.9 °C
• 精确质量: 382.989807
• PSA: 90.30000
• LogP: 1.39
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.638
• 储存条件: 室温

合成路线

185039-46-7 ~99% 185039-48-9

文献：SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH Patent: WO2004/63195 A1, 2004 ; Location in patent: Page 53; 55-56 ; WO 2004/063195 A1

185040-32-8 ~% 185039-48-9

文献：Klutchko, Sylvester R.; Hamby, James M.; Boschelli, Diane H.; Wu, Zhipei; Kraker, Alan J.; Amar, Aneesa M.; Hartl, Brian G.; Shen, Cynthia; Klohs, Wayne D.; Steinkampf, Randall W.; Driscoll, Denise L.; Nelson, James M.; Elliott, William L.; Roberts, Billy J.; Stoner, Chad L.; Vincent, Patrick W.; Dykes, Donald J.; Panek, Robert L.; Lu, Gina H.; Major, Terry C.; Dahring, Tawny K.; Hallak, Hussein; Bradford, Laura A.; Showalter, H. D. Hollis; Doherty, Annette M. Journal of Medicinal Chemistry, 1998 , vol. 41, # 17 p. 3276 - 3292

17759-30-7 ~% 185039-48-9

文献：Klutchko, Sylvester R.; Hamby, James M.; Boschelli, Diane H.; Wu, Zhipei; Kraker, Alan J.; Amar, Aneesa M.; Hartl, Brian G.; Shen, Cynthia; Klohs, Wayne D.; Steinkampf, Randall W.; Driscoll, Denise L.; Nelson, James M.; Elliott, William L.; Roberts, Billy J.; Stoner, Chad L.; Vincent, Patrick W.; Dykes, Donald J.; Panek, Robert L.; Lu, Gina H.; Major, Terry C.; Dahring, Tawny K.; Hallak, Hussein; Bradford, Laura A.; Showalter, H. D. Hollis; Doherty, Annette M. Journal of Medicinal Chemistry, 1998 , vol. 41, # 17 p. 3276 - 3292

5909-24-0 ~% 185039-48-9

文献：Klutchko, Sylvester R.; Hamby, James M.; Boschelli, Diane H.; Wu, Zhipei; Kraker, Alan J.; Amar, Aneesa M.; Hartl, Brian G.; Shen, Cynthia; Klohs, Wayne D.; Steinkampf, Randall W.; Driscoll, Denise L.; Nelson, James M.; Elliott, William L.; Roberts, Billy J.; Stoner, Chad L.; Vincent, Patrick W.; Dykes, Donald J.; Panek, Robert L.; Lu, Gina H.; Major, Terry C.; Dahring, Tawny K.; Hallak, Hussein; Bradford, Laura A.; Showalter, H. D. Hollis; Doherty, Annette M. Journal of Medicinal Chemistry, 1998 , vol. 41, # 17 p. 3276 - 3292

76360-82-2 ~% 185039-48-9

文献：Klutchko, Sylvester R.; Hamby, James M.; Boschelli, Diane H.; Wu, Zhipei; Kraker, Alan J.; Amar, Aneesa M.; Hartl, Brian G.; Shen, Cynthia; Klohs, Wayne D.; Steinkampf, Randall W.; Driscoll, Denise L.; Nelson, James M.; Elliott, William L.; Roberts, Billy J.; Stoner, Chad L.; Vincent, Patrick W.; Dykes, Donald J.; Panek, Robert L.; Lu, Gina H.; Major, Terry C.; Dahring, Tawny K.; Hallak, Hussein; Bradford, Laura A.; Showalter, H. D. Hollis; Doherty, Annette M. Journal of Medicinal Chemistry, 1998 , vol. 41, # 17 p. 3276 - 3292

185039-29-6 ~% 185039-48-9

文献：Klutchko, Sylvester R.; Hamby, James M.; Boschelli, Diane H.; Wu, Zhipei; Kraker, Alan J.; Amar, Aneesa M.; Hartl, Brian G.; Shen, Cynthia; Klohs, Wayne D.; Steinkampf, Randall W.; Driscoll, Denise L.; Nelson, James M.; Elliott, William L.; Roberts, Billy J.; Stoner, Chad L.; Vincent, Patrick W.; Dykes, Donald J.; Panek, Robert L.; Lu, Gina H.; Major, Terry C.; Dahring, Tawny K.; Hallak, Hussein; Bradford, Laura A.; Showalter, H. D. Hollis; Doherty, Annette M. Journal of Medicinal Chemistry, 1998 , vol. 41, # 17 p. 3276 - 3292

185039-37-6 ~% 185039-48-9

文献：Klutchko, Sylvester R.; Hamby, James M.; Boschelli, Diane H.; Wu, Zhipei; Kraker, Alan J.; Amar, Aneesa M.; Hartl, Brian G.; Shen, Cynthia; Klohs, Wayne D.; Steinkampf, Randall W.; Driscoll, Denise L.; Nelson, James M.; Elliott, William L.; Roberts, Billy J.; Stoner, Chad L.; Vincent, Patrick W.; Dykes, Donald J.; Panek, Robert L.; Lu, Gina H.; Major, Terry C.; Dahring, Tawny K.; Hallak, Hussein; Bradford, Laura A.; Showalter, H. D. Hollis; Doherty, Annette M. Journal of Medicinal Chemistry, 1998 , vol. 41, # 17 p. 3276 - 3292

3215-64-3 ~% 185039-48-9

文献：Palmer, Brian D.; Smaill, Jeff B.; Rewcastle, Gordon W.; Dobrusin, Ellen M.; Kraker, Alan; Moore, Charles W.; Steinkampf, Randall W.; Denny, William A. Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 7 p. 1931 - 1935

上下游产品

上游产品  8
185039-46-7 185040-32-8 17759-30-7 5909-24-0
76360-82-2 185039-29-6 185039-37-6 3215-64-3
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