26717-47-5

• 常用中文名：氯贝胺
• 常用英文名：clofibride
• CAS号：26717-47-5
• 分子式：C₁₆H₂₂ClNO₄
• 分子量：327.80300
• 相关类别： 研究领域 代谢疾病
• 发布时间：2018-06-20 16:54:28
• 更新时间：2024-01-11 12:11:45
• 氯原纤维是一种口服活性的多氯苯氧基异丁基降血脂剂。氯原纤维具有弱毒性和显著的低胆固醇血症和低甘油血症活性。氯原纤维在体内转化为4-氯苯氧基异丁酸(CPIB)和4-羟基-N-二甲基丁酰胺(HMB)[1]。

名称

• 中文名: 氯贝胺
• 英文名: [4-(dimethylamino)-4-oxobutyl] 2-(4-chlorophenoxy)-2-methylpropanoate
• 英文别名: Butyramide,N-dimethyl-4-(p-chlorophenoxyisobutyrate); Clofibride; Clofibrida [INN-Spanish]; N-Dimethyl-4-(p-chlorophenoxyisobutyrate)butyramide; MG 46; EINECS 247-912-7; Lipenan; 3-dimethylcarbamoylpropyl 2-(4-chlorophenoxy)-2-methylpropionate; Clofibridum [INN-Latin]

物化性质

• 密度: 1.163g/cm3
• 沸点: 448.7ºC at 760mmHg
• 分子式: C₁₆H₂₂ClNO₄
• 分子量: 327.80300
• 闪点: 225.2ºC
• 精确质量: 327.12400
• PSA: 55.84000
• LogP: 2.90900
• 蒸汽压: 3.04E-08mmHg at 25°C
• 折射率: 1.515

生物活性

• 描述: 氯原纤维是一种口服活性的多氯苯氧基异丁基降血脂剂。氯原纤维具有弱毒性和显著的低胆固醇血症和低甘油血症活性。氯原纤维在体内转化为4-氯苯氧基异丁酸(CPIB)和4-羟基-N-二甲基丁酰胺(HMB)[1]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 体内研究: 氯原纤维(口服,400；500和1000 mg/kg；单次)可快速且大量地再吸收并水解为4-氯苯氧基异丁酸(CPIB)和4-羟基-N-二甲基丁胺(HMB)[1]。动物模型：雄性CD大鼠、雄性和雌性比格犬、橄榄狒狒猴[1]剂量：4001000 mg/kg(大鼠)；500 mg/kg(狗和猴子)给药：口服,单次结果：HMB快速代谢,大鼠血清中主要活性代谢物CPIB的半衰期约为12小时,狗为43±9小时,狒狒为6±1小时。

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UE9458000 CHEMICAL NAME : Propionic acid, 2-(p-chlorophenoxy)-2-methyl-, ester with 4-hydroxy-N,N-dimethylbutyramide CAS REGISTRY NUMBER : 26717-47-5 LAST UPDATED : 199612 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C16-H22-Cl-N-O4 MOLECULAR WEIGHT : 327.84 WISWESSER LINE NOTATION : GR DOX1&1&VO3VN1&1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2485 mg/kg TOXIC EFFECTS : Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression REFERENCE : JETOAS Journal Europeen de Toxicologie. (Paris, France) V.1-6, 1968-72. For publisher information, see TOERD9. Volume(issue)/page/year: 5,239,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1175 mg/kg TOXIC EFFECTS : Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression REFERENCE : JETOAS Journal Europeen de Toxicologie. (Paris, France) V.1-6, 1968-72. For publisher information, see TOERD9. Volume(issue)/page/year: 5,239,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1080 mg/kg TOXIC EFFECTS : Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression REFERENCE : JETOAS Journal Europeen de Toxicologie. (Paris, France) V.1-6, 1968-72. For publisher information, see TOERD9. Volume(issue)/page/year: 5,239,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 960 mg/kg TOXIC EFFECTS : Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression REFERENCE : JETOAS Journal Europeen de Toxicologie. (Paris, France) V.1-6, 1968-72. For publisher information, see TOERD9. Volume(issue)/page/year: 5,239,1972 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 14 gm/kg SEX/DURATION : male 7 day(s) pre-mating female 7 day(s) pre-mating female 1-22 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - stillbirth REFERENCE : JETOAS Journal Europeen de Toxicologie. (Paris, France) V.1-6, 1968-72. For publisher information, see TOERD9. Volume(issue)/page/year: 5,239,1972

安全

• 海关编码: 2924299090

海关

海关编码	2924299090
中文概述	2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 包装
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%