137332-54-8

• 常用中文名：4,5,6,7-Tetrahydro-5α-methyl-6-(3-methyl-2-butenyl)-8-chloroimidazo[4,5,1-jk][1,4]benzodiazepine-2(1H)-thione
• 常用英文名：4,5,6,7-Tetrahydro-5α-methyl-6-(3-methyl-2-butenyl)-8-chloroimidazo[4,5,1-jk][1,4]benzodiazepine-2(1H)-thione
• CAS号：137332-54-8
• 分子式：C₁₇H₂₁ClN₂S
• 分子量：320.88000
• 发布时间：2017-09-08 11:36:53
• 更新时间：2024-04-02 09:58:01

名称

• 英文名: Tivirapine
• 英文别名: 8-Chloro-TIBO; 5-CHLORO-8-METHYL-7-(3-METHYL-BUT-2-ENYL)-6,7,8,9-TETRAHYDRO-2H-2,7,9A-TRIAZA-BENZO[CD]AZULENE-1-THIONE; 8-ClTIBO; 1uwb; (+)-(S)-8-chloro-4,5,6,7-tetrahydro-5-methyl-6-(3-methyl-2-butenyl)imidazo[4,5,1-jk][1,4]benzodiazepine-2(1H)-thione; (+)-(S)-4,5,6,7-Tetrahydro-8-chloro-5-methyl-6-(3-methyl-2-butenyl)imidazo<4,5,1-jk><1,4>benzodiazepine-2(1H)-thione

物化性质

• 密度: 1.25g/cm3
• 沸点: 446.1ºC at 760 mmHg
• 分子式: C₁₇H₂₁ClN₂S
• 分子量: 320.88000
• 闪点: 223.6ºC
• 精确质量: 320.11100
• PSA: 56.62000
• LogP: 5.14310
• 蒸汽压: 3.73E-08mmHg at 25°C
• 折射率: 1.642

合成路线

67-66-3 149976-82-9 ~90% 137332-54-8

文献：Janssen Pharmaceutica N.V. Patent: US5463049 A1, 1995 ;

137332-58-2 ~% 137332-54-8

文献：Ho; Kukla; Breslin; Ludovici; Grous; Diamond; Miranda; Rodgers; De Clercq; Pauwels; Andries; Janssen Journal of Medicinal Chemistry, 1995 , vol. 38, # 5 p. 794 - 802

55775-97-8 ~% 137332-54-8

文献：Parker, Kathlyn A.; Coburn, Craig A. Journal of Organic Chemistry, 1992 , vol. 57, # 1 p. 97 - 100

149976-82-9 6160-65-2 ~54% 137332-54-8

文献：Ho; Kukla; Breslin; Ludovici; Grous; Diamond; Miranda; Rodgers; De Clercq; Pauwels; Andries; Janssen Journal of Medicinal Chemistry, 1995 , vol. 38, # 5 p. 794 - 802

5866-97-7 ~% 137332-54-8

文献：Ho; Kukla; Breslin; Ludovici; Grous; Diamond; Miranda; Rodgers; De Clercq; Pauwels; Andries; Janssen Journal of Medicinal Chemistry, 1995 , vol. 38, # 5 p. 794 - 802

141114-44-5 ~% 137332-54-8

文献：Ho; Kukla; Breslin; Ludovici; Grous; Diamond; Miranda; Rodgers; De Clercq; Pauwels; Andries; Janssen Journal of Medicinal Chemistry, 1995 , vol. 38, # 5 p. 794 - 802

870-63-3 ~% 137332-54-8

文献：Ho; Kukla; Breslin; Ludovici; Grous; Diamond; Miranda; Rodgers; De Clercq; Pauwels; Andries; Janssen Journal of Medicinal Chemistry, 1995 , vol. 38, # 5 p. 794 - 802

75-15-0 149976-82-9 ~% 137332-54-8

文献：Parker, Kathlyn A.; Coburn, Craig A. Journal of Organic Chemistry, 1992 , vol. 57, # 1 p. 97 - 100