320347-97-5

• 常用中文名：2-Thiopheneacetic acid, α-hydroxy-α-2-thienyl-, (3R)-1-azabicyclo[2.2.2]oct-3-yl ester
• 常用英文名：2-Thiopheneacetic acid, α-hydroxy-α-2-thienyl-, (3R)-1-azabicyclo[2.2.2]oct-3-yl ester
• CAS号：320347-97-5
• 分子式：C₁₇H₁₉NO₃S₂
• 分子量：349.46800
• 发布时间：2017-08-29 07:49:05
• 更新时间：2024-01-07 23:00:01

名称

• 英文名: 1-Azabicyclo[2.2.2]oct-3-yl hydroxy(di-2-thienyl)acetate
• 英文别名: hydroxy-dithiophen-2-yl-acetic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl) ester; (3R)-1-azabicyclo[2.2.2]oct-3-yl hydroxy(di-2-thienyl)acetate; monohydroxydibenzothiophene; 3-Hydroxydiphenylenesulfide; dibenzo[b,d]thiophen-2-ol; D-Hyicap-OtBu; 2-hydroxy-2,2-dithien-2-ylacetic acid (R)-1-azabicyclo[2.2.2]oct-3-yl ester; 2-hydroxy-2,2-dithien-2-ylacetic acid (3R)-1-azabicyclo[2.2.2]oct-3-yl ester; 2-hydroxydibenzothiophene; 2-hydroxy-dithiophen-2-yl-acetic acid (R)-(1-azabicyclo[2.2.2]oct-3-yl) ester; Dibenzothiophene-2-ol; 2-Hydroxy-D-isocapronsaeure-tert-butylester; (3R)-1-azabicyclo[2.2.2]oct-3-yl hydroxy(dithiophen-2-yl)acetate

物化性质

• 分子式: C₁₇H₁₉NO₃S₂
• 分子量: 349.46800
• 精确质量: 349.08100
• PSA: 106.25000
• LogP: 2.62080

合成路线

28569-88-2 25333-42-0 ~% 320347-97-5

文献：RANBAXY LABORATORIES LIMITED Patent: US2009/326004 A1, 2009 ; Location in patent: Page/Page column 8 ;

26447-85-8 25333-42-0 ~51% 320347-97-5

文献：Prat, Maria; Fernandez, Dolors; Buil, M. Antonia; Crespo, Maria I.; Casals, Gaspar; Ferrer, Manuel; Tort, Laia; Castro, Jordi; Monleon, Juan M.; Gavalda, Amadeu; Miralpeix, Montserrat; Ramos, Israel; Domenech, Teresa; Vilella, Dolors; Anton, Francisca; Huerta, Josep M.; Espinosa, Sonia; Lopez, Manuel; Sentellas, Sonia; Gonzalez, Marisa; Alberti, Joan; Segarra, Victor; Cardenas, Alvaro; Beleta, Jorge; Ryder, Hamish Journal of Medicinal Chemistry, 2009 , vol. 52, # 16 p. 5076 - 5092

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