642-72-8

• 常用中文名：苄达明
• 常用英文名：benzydamine
• CAS号：642-72-8
• 分子式：C₁₉H₂₃N₃O
• 分子量：309.405
• 相关类别： 原料药 解热镇痛药 非甾抗炎药
• 发布时间：2018-07-10 11:23:43
• 更新时间：2024-01-02 11:24:27
• 【用途一】
  用作消炎镇痛药

名称

• 中文名: 苄达明
• 英文名: 3-(1-benzylindazol-3-yl)oxy-N,N-dimethylpropan-1-amine
• 中文别名: 1-苄基-3-[3-(二甲基氨基)丙氧基]-1H-吲唑
• 英文别名: Benzydaminum [INN-Latin]; Benzydamine [INN:BAN]; Bencidamina [INN-Spanish]; 1-Benzyl-3-[3-(dimethylamino)propoxy]-1H-indazole; 1-Propanamine, N,N-dimethyl-3-[[1-(phenylmethyl)-1H-indazol-3-yl]oxy]-; benzydamine; C 1523; Benzidamina [DCIT]; 1-Propanamine, N,N-dimethyl-3-((1-(phenylmethyl)-1H-indazol-3-yl)oxy)-; benzidamine; 1H-Indazole,1-benzyl-3-(3-(dimethylamino)propoxy); MFCD00864286; 3-[(1-Benzyl-1H-indazol-3-yl)oxy]-N,N-dimethylpropan-1-amin; 3-[(1-benzyl-1H-indazol-3-yl)oxy]-N,N-dimethylpropan-1-amine; benzindamine; EINECS 211-388-8; 1-Benzyl-1H-indazol-3-yl 3-(Dimethylamino)propyl Ether; [3-(1-benzyl-1H-indazol-3-yloxy)-propyl]-dimethyl-amine; 3-[(1-Benzyl-1H-indazol-3-yl)oxy]-N,N-dimethyl-1-propanamine

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 474.4±35.0 °C at 760 mmHg
• 分子式: C₁₉H₂₃N₃O
• 分子量: 309.405
• 闪点: 240.7±25.9 °C
• 精确质量: 309.184113
• PSA: 30.29000
• LogP: 3.78
• 外观性状: 粉红色固体
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.580
• 储存条件: 通风低温干燥,与库房食品原料分开存放

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NK7790000 CHEMICAL NAME : 1H-Indazole, 1-benzyl-3-(3-(dimethylamino)propoxy)- CAS REGISTRY NUMBER : 642-72-8 BEILSTEIN REFERENCE NO. : 0896536 LAST UPDATED : 199612 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C19-H23-N3-O MOLECULAR WEIGHT : 309.45 WISWESSER LINE NOTATION : T56 BNNJ B1R& DO3N1&1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 950 mg/kg TOXIC EFFECTS : Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 15,41,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 460 mg/kg TOXIC EFFECTS : Behavioral - ataxia Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 23,1266,1973 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 109 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 15,471,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 445 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - convulsions or effect on seizure threshold REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 6,1285,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 25 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - convulsions or effect on seizure threshold REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 6,1285,1972 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 8925 mg/kg/21D-I TOXIC EFFECTS : Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Related to Chronic Data - changes in testicular weight REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 22,226,1972

安全

• 海关编码: 2933990090

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37598-92-8

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%