CHEMICAL IDENTIFICATION
-
RTECS NUMBER :
-
AY3980000
-
CHEMICAL NAME :
-
Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, hydrochloride, DL
-
CAS REGISTRY NUMBER :
-
1465-26-5
-
LAST UPDATED :
-
199707
-
DATA ITEMS CITED :
-
20
-
MOLECULAR FORMULA :
-
C13-H18-Cl2-N2-O2.Cl-H
-
MOLECULAR WEIGHT :
-
341.69
-
WISWESSER LINE NOTATION :
-
QVYZ1R DN2G2G &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
52 mg/kg
-
TOXIC EFFECTS :
-
Gastrointestinal - hypermotility, diarrhea Endocrine - changes in spleen weight Blood - changes in bone marrow (not otherwise specified)
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
16200 ug/kg
-
TOXIC EFFECTS :
-
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Gastrointestinal - hypermotility, diarrhea Blood - changes in bone marrow (not otherwise specified)
-
TYPE OF TEST :
-
LDLo - Lowest published lethal dose
-
ROUTE OF EXPOSURE :
-
Intratracheal
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
5 mg/kg
-
TOXIC EFFECTS :
-
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) Blood - changes in bone marrow (not otherwise specified)
-
TYPE OF TEST :
-
LDLo - Lowest published lethal dose
-
ROUTE OF EXPOSURE :
-
Unreported
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
15 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
44600 ug/kg
-
TOXIC EFFECTS :
-
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Gastrointestinal - hypermotility, diarrhea Blood - changes in bone marrow (not otherwise specified)
-
TYPE OF TEST :
-
LDLo - Lowest published lethal dose
-
ROUTE OF EXPOSURE :
-
Unreported
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
20 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LDLo - Lowest published lethal dose
-
ROUTE OF EXPOSURE :
-
Intravenous
-
SPECIES OBSERVED :
-
Mammal - dog
-
DOSE/DURATION :
-
430 ug/kg
-
TOXIC EFFECTS :
-
Blood - leukopenia Blood - thrombocytopenia Blood - other changes
-
TYPE OF TEST :
-
LDLo - Lowest published lethal dose
-
ROUTE OF EXPOSURE :
-
Intravenous
-
SPECIES OBSERVED :
-
Primate - monkey
-
DOSE/DURATION :
-
860 ug/kg
-
TOXIC EFFECTS :
-
Gastrointestinal - other changes Blood - leukopenia Blood - other changes
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
41600 ug/kg/13W-I
-
TOXIC EFFECTS :
-
Endocrine - changes in spleen weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood - changes in leukocyte (WBC) count
-
TYPE OF TEST :
-
TCLo - Lowest published toxic concentration
-
ROUTE OF EXPOSURE :
-
Inhalation
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
1 mg/m3/2H/30D-I
-
TOXIC EFFECTS :
-
Kidney, Ureter, Bladder - other changes in urine composition Blood - changes in spleen Blood - changes in leukocyte (WBC) count
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
66 mg/kg/1Y-I
-
TOXIC EFFECTS :
-
Blood - changes in spleen Related to Chronic Data - death
MUTATION DATA
-
TYPE OF TEST :
-
DNA damage
-
TEST SYSTEM :
-
Rodent - hamster Fibroblast
-
DOSE/DURATION :
-
1200 umol/L
-
REFERENCE :
-
BEXBAN Bulletin of Experimental Biology and Medicine (English Translation). Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.41- 1956- Volume(issue)/page/year: 92,943,1981
|
