6834-98-6

• 常用中文名：喷他霉素
• 常用英文名：Lagosin
• CAS号：6834-98-6
• 分子式：C₃₅H₅₈O₁₂
• 分子量：670.83
• 相关类别： 信号通路 抗感染 真菌
• 发布时间：2018-09-27 20:18:43
• 更新时间：2024-01-06 16:23:52
• Lagosin(Fungichromin)是一种多烯大环内酯类抗生素。Lagosin具有广谱抗真菌活性,不受耐药性影响[1]。

名称

• 中文名: 喷他霉素
• 英文名: (3R,4S,6S,8S,10R,12R,14R,15R,16R,17E,19E,21E,23E,25E,27S,28R)-4,6,8,10,12,14,15,16,27-nonahydroxy-3-[(1R)-1-hydroxyhexyl]-17,28-dimethyl-1-oxacyclooctacosa-17,19,21,23,25-pentaen-2-one
• 英文别名: Pentamycin; S 232; all-trans-3,5,7,9,11,13,14,15,26,27-Decahydroxy-2,1'-hydroxyhexyl-16-methyl-octacosa-16,18,20,22,24-pentaen-saeure-1->27-lacton; 14-Hydroxyfilipin; Cogomycin; Antibiotic A-246; Lagosin (antibiotic); EINECS 229-913-4; Lagosin; Fungichromin

物化性质

• 密度: 1.196g/cm3
• 沸点: 914ºC at 760 mmHg
• 分子式: C₃₅H₅₈O₁₂
• 分子量: 670.83
• 闪点: 278.4ºC
• 精确质量: 670.39300
• PSA: 228.60000
• LogP: 0.85880
• 折射率: 1.545

生物活性

• 描述: Lagosin(Fungichromin)是一种多烯大环内酯类抗生素。Lagosin具有广谱抗真菌活性,不受耐药性影响[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 抗感染 >> 真菌
• 体外研究: 大别山松内生菌链霉菌WP-1产生Lagosin及其对尖孢镰刀菌的抗真菌活性[1]。
• 参考文献:

  [1]. Peng C, et al. Fungichromin production by Streptomyces sp. WP-1, an endophyte from Pinus dabeshanensis, and its antifungal activity against Fusarium oxysporum. Appl Microbiol Biotechnol. 2020;104(24):10437-10449.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : LT3850000 CHEMICAL NAME : Fungichromin CAS REGISTRY NUMBER : 6834-98-6 LAST UPDATED : 199512 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C35-H58-O12 MOLECULAR WEIGHT : 670.93 WISWESSER LINE NOTATION : T-28-OV RU TU VU A&U C&UTJ CYQ5 DQ FQ HQ JQ LQ NQ OQ PQ R1 E&Q F&1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1624 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 11,26,1958 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 16400 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher information, see AMACCQ. Volume(issue)/page/year: 2,716,1954/1955