655-35-6

• 常用中文名：乙胺香豆素盐酸盐
• 常用英文名：Chromonar hydrochloride
• CAS号：655-35-6
• 分子式：C₂₀H₂₈ClNO₅
• 分子量：397.89300
• 发布时间：2018-02-12 08:00:00
• 更新时间：2024-01-24 17:28:23
• Chromonar hydrochloride is a coronary vasodilator agent. It increases in transmural blood flow.

名称

• 中文名: 乙胺香豆素盐酸盐
• 英文名: Acetic acid,2-[[3-[2-(diethylamino)ethyl]-4-methyl-2-oxo-2H-1-benzopyran-7-yl]oxy]-, ethylester, hydrochloride (1:1)
• 英文别名: Carboc; Carbochromen-hydrochlorid; intercordin; carbocromene; CarbochroMen Hydrochloride; intensain hydrochloride; antiangor; CARBOCROMENE HYDROCHLORIDE; carbocromen hydrochloride; carbochromene hydrochloride

物化性质

• 沸点: 488.6ºC at 760 mmHg
• 熔点: 159-160ºC
• 分子式: C₂₀H₂₈ClNO₅
• 分子量: 397.89300
• 闪点: 249.3ºC
• 精确质量: 397.16600
• PSA: 68.98000
• LogP: 3.72960
• 储存条件: 库房低温通风干燥

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : AG9500000 CHEMICAL NAME : Acetic acid, ((3-(2-(diethylamino)ethyl)-4-methyl-2-oxo)-2H-1-benz opyran-7-yl)oxy-, ethyl ester, hydrochloride CAS REGISTRY NUMBER : 655-35-6 LAST UPDATED : 199706 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C20-H27-N-O5.Cl-H MOLECULAR WEIGHT : 397.94 WISWESSER LINE NOTATION : L66 BOVT&J D2N2&2 E1 IO1VO2 &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 8 gm/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 27(4),48,1983 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 6300 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 13,243,1963 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 528 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 13,243,1963 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 34 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 9,57,1975 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 173 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 13,243,1963 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 30 mg/m3/17W-I TOXIC EFFECTS : Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases REFERENCE : GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 27(4),48,1983 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.3 mg/m3 JAN 1993