41451-75-6

• 常用中文名：鸦胆亭
• 常用英文名：Bruceantin
• CAS号：41451-75-6
• 分子式：C₂₈H₃₆O₁₁
• 分子量：548.579
• 相关类别： 天然产物 其他
• 发布时间：2018-04-21 08:00:00
• 更新时间：2024-01-02 13:28:32
• Bruceantin(NSC165563)可从痢鸦胆子中提取，对B16黑色素瘤，结肠癌38，L1210和白血病P388有抑制性。

名称

• 中文名: 鸦胆亭
• 英文名: Bruceantin
• 中文别名: 鸦胆停
• 英文别名: [11b,12a,15b(E)]-15-[(3,4-Dimethyl-1-oxo-2-pentenyl)oxy]-13,20-epoxy-3,11,12-trihydroxy-2,16-dioxopicras-3-en-21-oic Acid Methyl Ester; Methyl (11β,12α,15β)-15-{[(2E)-3,4-dimethyl-2-pentenoyl]oxy}-3,11,12-trihydroxy-2,16-dioxo-13,20-epoxypicras-3-en-21-oate; Methyl (11β,12α,15β)-15-{[(2E)-3,4-dimethylpent-2-enoyl]oxy}-3,11,12-trihydroxy-2,16-dioxo-13,20-epoxypicras-3-en-21-oate; Picras-3-en-21-oic acid, 15-[[(2E)-3,4-dimethyl-1-oxo-2-penten-1-yl]oxy]-13,20-epoxy-3,11,12-trihydroxy-2,16-dioxo-, methyl ester, (11β,12α,15β)-

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 731.0±60.0 °C at 760 mmHg
• 分子式: C₂₈H₃₆O₁₁
• 分子量: 548.579
• 闪点: 239.4±26.4 °C
• 精确质量: 548.225769
• PSA: 165.89000
• LogP: 2.96
• 蒸汽压: 0.0±5.4 mmHg at 25°C
• 折射率: 1.598
• 储存条件: -20°C

生物活性

• 描述: Bruceantin(NSC165563)可从痢鸦胆子中提取,对B16黑色素瘤,结肠癌38,L1210和白血病P388有抑制性。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 癌症
  天然产物 >> 其他
• 参考文献:

  [1]. Cuendet M, et al. Multiple myeloma regression mediated by bruceantin. Clin Cancer Res. 2004 Feb 1;10(3):1170-9.

  [2]. Cuendet M, et al. Antitumor activity of bruceantin: an old drug with new promise. J Nat Prod. 2004 Feb;67(2):269-72.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : EH8798000 CHEMICAL NAME : Bruceantin CAS REGISTRY NUMBER : 41451-75-6 LAST UPDATED : 198605 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C28-H36-O11 MOLECULAR WEIGHT : 548.64 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 7027 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2727 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3359 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1950 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 500 ug/kg TOXIC EFFECTS : Gastrointestinal - hypermotility, diarrhea Gastrointestinal - other changes Blood - hemorrhage MUTATION DATA TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Rodent - mouse Lymphocyte DOSE/DURATION : 15 umol/L REFERENCE : JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 68,883,1979

合成路线

63306-30-9 ~% 41451-75-6

文献：Hall; Lee; Okano; Sims; Ibuka; Liou; Imakura Journal of Pharmaceutical Sciences, 1981 , vol. 70, # 10 p. 1147 - 1150

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