320-77-4

• 常用中文名：异柠檬酸
• 常用英文名：3-carboxy-2,3-dideoxy-1-hydroxypropan-1,2,3-tricarboxylic acid
• CAS号：320-77-4
• 分子式：C₆H₈O₇
• 分子量：192.12400
• 相关类别： 研究领域 神经疾病
• 发布时间：2018-02-12 08:00:00
• 更新时间：2024-01-01 21:58:14
• 异柠檬酸是唾液和细胞浆中存在的一种内源性代谢产物,可用于阿尔茨海默病、路易体痴呆和缺氧的研究[1][2][3]。

名称

• 中文名: 异柠檬酸
• 英文名: isocitric acid
• 英文别名: 1-hydroxypropane-1,2,3-tricarboxylic acid; 1-Hydroxy-propan-1,2,3-tricarbonsaeure; 1-hydroxy-propane-1,2,3-tricarboxylic acid; 3-Methylsaeure-pentanol-(2)-disaeure; I-CIT; D-isocitrate; isocitrate; 1-Hydroxytricarballylic acid; 1-Hydroxy-1,2,3-propanetricarboxylic acid; 3-Carboxy-2,3-dideoxy-1-hydroxypropan-1,2,3-tricarboxylic acid

物化性质

• 密度: 1.751g/cm3
• 沸点: 329.6ºC at 760 mmHg
• 分子式: C₆H₈O₇
• 分子量: 192.12400
• 闪点: 167.4ºC
• 精确质量: 192.02700
• PSA: 132.13000
• 折射率: 1.569

生物活性

• 描述: 异柠檬酸是唾液和细胞浆中存在的一种内源性代谢产物,可用于阿尔茨海默病、路易体痴呆和缺氧的研究[1][2][3]。
• 相关类别:
  研究领域 >> 神经疾病
• 靶点:

  Human Endogenous Metabolite

• 体外研究: 内源性代谢产物被定义为《京都基因和基因组百科全书》注释为我们基因组中约1900种代谢酶的底物或产物。在文献正文中很清楚,许多这些代谢产物都具有毒性[1]。
• 参考文献:

  [1]. Lee N, et al. Endogenous toxic metabolites and implications in cancer therapy. Oncogene. 2020 Aug;39(35):5709-5720.

  [2]. Tsuruoka M, et al. Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients. Electrophoresis. 2013 Oct;34(19):2865-72.

  [3]. Zupke C, et al. Intracellular flux analysis applied to the effect of dissolved oxygen on hybridomas. Appl Microbiol Biotechnol. 1995 Dec;44(1-2):27-36.

合成路线

328-50-7 124-38-9 ~98% 320-77-4

文献：Sugimura, Kenji; Kuwabata, Susumu; Yoneyama, Hiroshi Journal of the American Chemical Society, 1989 , vol. 111, # 6 p. 2361 - 2362

629-59-4 ~% 320-77-4 1731-88-0

文献：Terasawa, Masato; Takahashi, Joji Agricultural and Biological Chemistry, 1981 , vol. 45, # 11 p. 2433 - 2442

112-72-1 ~% 320-77-4 1731-88-0

文献：Terasawa, Masato; Takahashi, Joji Agricultural and Biological Chemistry, 1981 , vol. 45, # 11 p. 2433 - 2442

585-84-2 ~% 320-77-4

文献：Krebs; Holzach Biochemical Journal, 1952 , vol. 52, p. 527 Full Text View citing articles Show Details Friedrich-Freksa; Martius Zeitschrift fuer Naturforschung, 1951 , vol. 6b, p. 296

1120-36-1 ~% 56009-40-6 320-77-4 2345-27-9 详细

文献：Terasawa, Masato; Takahashi, Joji Agricultural and Biological Chemistry, 1981 , vol. 45, # 11 p. 2433 - 2442

2280-44-6 ~% 320-77-4 77-92-9

文献：Oogaki, Masako; Inoue, Madoka; Kaimaktchiev, Atanas C.; Nakahara, Tadaatsu; Tabuchi, Takeshi Agricultural and Biological Chemistry, 1984 , vol. 48, # 3 p. 789 - 796

7647-01-0 2393-15-9 ~% 320-77-4

文献：Greenstein Journal of Biological Chemistry, 1936 , vol. 116, p. 463,466 Full Text Show Details Pucher; Vickery Journal of Biological Chemistry, 1946 , vol. 163, p. 181

5910-08-7 ~% 320-77-4

文献：Fittig; Miller Justus Liebigs Annalen der Chemie, 1889 , vol. 255, p. 43,46