13292-22-3

• 常用中文名：3甲酰利福平霉素
• 常用英文名：3-Formyl Rifamycin
• CAS号：13292-22-3
• 分子式：C₃₈H₄₇NO₁₃
• 分子量：725.779
• 相关类别： 原料药 抗生素类药物 利福霉素类药
• 发布时间：2018-02-09 08:00:00
• 更新时间：2024-01-02 18:08:55
• 3-Formyl rifamycin 是Rifampicin 的一个中间体。

名称

• 中文名: 3-甲酰利福平霉素
• 英文名: 3-Formyl Rifamycin
• 中文别名: 3-甲酸基利福霉素 sv; 3-甲酰基利福霉素; 三甲酰利福霉素SV; 3-甲酰利福霉素SV; 3-甲酰基-利福霉素
• 英文别名: (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-26-Formyl-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1.0]triaconta-1( 
29),2,4,9,19,21,25,27-octaen-13-yl acetate; (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-26-Formyl-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1.0]triaconta-1(28),2,4,9,19,21,25(29),26-octaen-13-yl acetate; 2,7-(Epoxy[1,11,13]pentadecatrienoimino)naphtho[2,1-b]furan-8-carboxaldehyde, 21-(acetyloxy)-1,2-dihydro-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-, (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-; 3-Formylrifamycin

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 855.4±65.0 °C at 760 mmHg
• 熔点: 182-184°C
• 分子式: C₃₈H₄₇NO₁₃
• 分子量: 725.779
• 闪点: 471.1±34.3 °C
• 精确质量: 725.304749
• PSA: 218.38000
• LogP: 2.85
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.633
• 储存条件: -20°C Freezer, Under Inert Atmosphere

生物活性

• 描述: 3-Formyl rifamycin 是Rifampicin 的一个中间体。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : KD1600000 CHEMICAL NAME : 2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b) furan-8-carboxaldehyd e, 1,2-dihydro-5, 6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,2 2-heptamethyl-1,11-di oxo-, 21-acetate CAS REGISTRY NUMBER : 13292-22-3 LAST UPDATED : 199703 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C38-H47-N-O13 MOLECULAR WEIGHT : 725.86 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 907 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4002754 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 416 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4002754 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 299 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 38KLAC "Structure-Activity Relationship among the Semisynthetic Antibiotics," Perlman, D., ed., New York, Academic Press, 1977 Volume(issue)/page/year: -,531,1977

合成路线

13292-46-1 ~88% 13292-22-3

文献：Pyta, Krystian; Przybylski, Piotr; Wicher, Barbara; Gdaniec, Maria; Stefanska, Joanna Organic and Biomolecular Chemistry, 2012 , vol. 10, # 12 p. 2385 - 2388

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