27591-97-5

• 常用中文名：替洛隆
• 常用英文名：Tilorone
• CAS号：27591-97-5
• 分子式：C₂₅H₃₄N₂O₃
• 分子量：410.549
• 相关类别： 原料药 人工合成抗感染类药 抗病毒类药
• 发布时间：2018-03-20 08:00:00
• 更新时间：2024-01-04 21:12:50

名称

• 中文名: 乙胺芴酮
• 英文名: 2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one
• 中文别名: 泰洛伦; 2,7-双[2-(二乙基氨基)乙氧基]-9-芴酮
• 英文别名: UNII-O6W7VEW6KS; Tilorone; Amixin IC; 2,7-Bis-DEAE-fluorenone; Tilorone base; Tilorone hydrochloride; 2,7-Bis[2-(diethylamino)ethoxy]-9H-fluoren-9-one; 9H-Fluoren-9-one, 2,7-bis[2-(diethylamino)ethoxy]-; Bis-DEAE-fluorenone; 9H-Fluoren-9-one, 2,7-bis(2-(diethylamino)ethoxy)-; L B656 HVJ EO2N2&2 KO2N2&2

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 552.3±50.0 °C at 760 mmHg
• 分子式: C₂₅H₃₄N₂O₃
• 分子量: 410.549
• 闪点: 287.8±30.1 °C
• 精确质量: 410.256958
• PSA: 42.01000
• LogP: 5.25
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.564
• 储存条件: -20°C

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : LL8990000 CHEMICAL NAME : 9H-Fluoren-9-one, 2,7-bis(2-(diethylamino)ethoxy)- CAS REGISTRY NUMBER : 27591-97-5 LAST UPDATED : 199612 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C25-H34-N2-O3 MOLECULAR WEIGHT : 410.61 WISWESSER LINE NOTATION : L B656 HVJ EO2N2&2 KO2N2&2 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1780 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 121 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Immunological Including Allergic - increased immune response Tumorigenic - active as anti-cancer agent MUTATION DATA TYPE OF TEST : DNA inhibition TEST SYSTEM : Mammal - species unspecified Lymphocyte DOSE/DURATION : 100 umol/L REFERENCE : CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 11,91,1975

合成路线

27591-69-1 ~82% 27591-97-5

文献：Schulze; Letsch; Gutsche; et al. Pharmazie, 1984 , vol. 39, # 5 p. 320 - 322

42523-29-5 869-24-9 ~% 27591-97-5

文献：Burke,S.M.; Joullie,M.M. Synthetic Communications, 1976 , vol. 6, p. 371 - 376

53133-99-6 869-24-9 ~% 27591-97-5

文献：Burke,S.M.; Joullie,M.M. Synthetic Communications, 1976 , vol. 6, p. 371 - 376

1010786-65-8 ~% 27591-97-5

文献：Epperson, James R.; Bruce, Marc A.; Catt, John D.; Deskus, Jeffrey A.; Hodges, Donald B.; Karageorge, George N.; Keavy, Daniel J.; Mahle, Cathy D.; Mattson, Ronald J.; Ortiz, Astrid A.; Parker, Michael F.; Takaki, Katherine S.; Watson, Brett T.; Yevich, Joseph P. Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 17 p. 4601 - 4611

31551-45-8 ~% 27591-97-5

文献：Burke,S.M.; Joullie,M.M. Synthetic Communications, 1976 , vol. 6, p. 371 - 376

53134-09-1 ~% 27591-97-5

文献：Burke,S.M.; Joullie,M.M. Synthetic Communications, 1976 , vol. 6, p. 371 - 376

2915-84-6 ~% 27591-97-5

文献：Burke,S.M.; Joullie,M.M. Synthetic Communications, 1976 , vol. 6, p. 371 - 376

100-37-8 ~% 27591-97-5

文献：Karpinchik; Mal'tsev; Sumrii Pharmaceutical Chemistry Journal, 2002 , vol. 36, # 8 p. 448 - 450