953070-72-9

• 常用中文名：4-(Bromomethyl)-7,8-difluoro-2(1H)-quinolinone
• 常用英文名：4-(Bromomethyl)-7,8-difluoro-2(1H)-quinolinone
• CAS号：953070-72-9
• 分子式：C₁₀H₆BrF₂NO
• 分子量：274.061
• 发布时间：2016-08-14 18:55:15
• 更新时间：2025-08-26 00:29:27

名称

• 英文名: 4-(bromomethyl)-7,8-difluoro-1H-quinolin-2-one
• 英文别名: 4-(Bromomethyl)-7,8-difluoro-2(1H)-quinolinone; 2(1H)-Quinolinone, 4-(bromomethyl)-7,8-difluoro-; 4-(Bromomethyl)-7,8-difluoroquinolin-2(1H)-one

物化性质

• 密度: 1.7±0.1 g/cm3
• 沸点: 363.0±42.0 °C at 760 mmHg
• 分子式: C₁₀H₆BrF₂NO
• 分子量: 274.061
• 闪点: 173.3±27.9 °C
• 精确质量: 272.960083
• PSA: 32.86000
• LogP: 2.60
• 蒸汽压: 0.0±0.8 mmHg at 25°C
• 折射率: 1.577

合成路线

953071-01-7 ~89% 953070-72-9

文献：Payne, Joseph E.; Bonnefous, Celine; Symons, Kent T.; Nguyen, Phan M.; Sablad, Marciano; Rozenkrants, Natasha; Zhang, Yan; Wang, Li; Yazdani, Nahid; Shiau, Andrew K.; Noble, Stewart A.; Rix, Peter; Rao, Tadimeti S.; Hassig, Christian A.; Smith, Nicholas D. Journal of Medicinal Chemistry, 2010 , vol. 53, # 21 p. 7739 - 7755

4519-40-8 ~% 953070-72-9

文献：Duron, Sergio G.; Lindstrom, Andrew; Bonnefous, Celine; Zhang, Hui; Chen, Xiaohong; Symons, Kent T.; Sablad, Marciano; Rozenkrants, Natasha; Zhang, Yan; Wang, Li; Yazdani, Nahid; Shiau, Andrew K.; Noble, Stewart A.; Rix, Peter; Rao, Tadimeti S.; Hassig, Christian A.; Smith, Nicholas D. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 2 p. 1237 - 1241

1125702-46-6 ~% 953070-72-9

文献：Duron, Sergio G.; Lindstrom, Andrew; Bonnefous, Celine; Zhang, Hui; Chen, Xiaohong; Symons, Kent T.; Sablad, Marciano; Rozenkrants, Natasha; Zhang, Yan; Wang, Li; Yazdani, Nahid; Shiau, Andrew K.; Noble, Stewart A.; Rix, Peter; Rao, Tadimeti S.; Hassig, Christian A.; Smith, Nicholas D. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 2 p. 1237 - 1241

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953071-01-7 4519-40-8 1125702-46-6
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