1425-61-2

• 常用中文名：硫酸双氢链霉素
• 常用英文名：dihydrostreptomycin sesquisulfate salt
• CAS号：1425-61-2
• 分子式：C₄₂H₈₈N₁₄O₃₆S₃
• 分子量：1461.415
• 相关类别： 原料药 抗生素类药物 氨基糖苷类药
• 发布时间：2018-05-12 08:00:00
• 更新时间：2024-01-19 12:49:34

名称

• 中文名: 硫酸二氢链霉素
• 英文名: 2-[(1R,2R,3S,4R,5R,6S)-3-(diaminomethylideneamino)-4-[(2R,3R,4R,5S)-3-[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy-4-hydroxy-4-(hydroxymethyl)-5-methyloxolan-2-yl]oxy-2,5,6-trihydroxycyclohexyl]guanidine,sulfuric acid
• 中文别名: 硫酸双氢链霉素
• 英文别名: didromycin; dihydrostreptomycin3/2sulfate; Guanidine, N'',N'''''-[(1S,2S,3R,4S,5S,6R)-4-[[5-deoxy-2-O-[2-deoxy-2-(methylamino)-α-L-glucopyranosyl]-3-C-(hydroxymethyl)-α-L-lyxofuranosyl]oxy]-2,5,6-trihydroxy-1,3-cyclohexanediyl]bis-, su lfate (2:3) (salt); didromycine; panstreptin; dihydrostreptomycin sesquisulfate; Sol-Mycin; Prestwick_173; dihydrostreptomycin,sulfate; Double-Mycin; 2,2'-[(1S,2S,3R,4S,5S,6R)-4-({5-Deoxy-2-O-[2-deoxy-2-(methylamino)-α-L-glucopyranosyl]-3-C-(hydroxymethyl)-α-L-lyxofuranosyl}oxy)-2,5,6-trihydroxy-1,3-cyclohexanediyl]diguanidine sulfate (2:3); dihydrostreptomycin solution; Dihydrostreptomycin,Sufat; StreptoMagna

物化性质

• 沸点: 954.5ºC at 760 mmHg
• 分子式: C₄₂H₈₈N₁₄O₃₆S₃
• 分子量: 1461.415
• 闪点: 531.1ºC
• 精确质量: 1460.464722
• PSA: 918.12000
• 外观性状: crystalline
• 储存条件: 2-8°C
• 水溶解性: H2O: 50 mg/mL, clear, faintly yellow

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : WK4950000 CHEMICAL NAME : Streptomycin, dihydro-, sulfate CAS REGISTRY NUMBER : 1425-61-2 LAST UPDATED : 199112 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C21-H41-N7-O12.xH2-O4-S MOLECULAR WEIGHT : 1270.25 WISWESSER LINE NOTATION : T6OTJ CM1 DQ EQ F1Q BO- CT5OTJ DQ D1Q E1 BO- AL6TJ BQ CQ DMYZUM EQ FMYZUM &WSQQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,597,1962 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >600 mg/kg TOXIC EFFECTS : Behavioral - ataxia REFERENCE : ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 1,49,1951 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1380 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,285,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 761 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 18,444,1973 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 137 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 18,444,1973 *** REVIEWS *** TOXICOLOGY REVIEW PMMDAE Panminerva Medica. (Edizioni Minerva Medica, Casella Postale 491, Turin, Italy) V.1- 1959- Volume(issue)/page/year: 16,9,1974

安全

• WGK德国: 3
• RTECS号: WK2236000