76145-76-1

• 常用中文名：托莫普罗
• 常用英文名：Tomoxiprole
• CAS号：76145-76-1
• 分子式：C₂₁H₂₀N₂O
• 分子量：316.39600
• 发布时间：2018-06-26 11:12:06
• 更新时间：2024-01-09 11:23:03

名称

• 中文名: 托莫普罗
• 英文名: 2-(4-methoxyphenyl)-3-propan-2-ylbenzo[e]benzimidazole
• 英文别名: Tomoxiprolum; S085; 3-(1-methylethyl)-2-(4-methoxyphenyl)-3H-naphth<1,2-d>imidazole; UNII-EZ948T2878; Tomoxiprole; MDL-035

物化性质

• 密度: 1.178g/cm3
• 沸点: 529.1ºC at 760 mmHg
• 分子式: C₂₁H₂₀N₂O
• 分子量: 316.39600
• 闪点: 186.5ºC
• 精确质量: 316.15800
• PSA: 27.05000
• LogP: 5.44600
• 折射率: 1.666

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : QK9343000 CHEMICAL NAME : 3H-Naphth(1,2-d)imidazole, 2-(4-methoxyphenyl)-3-(1-methylethyl)- CAS REGISTRY NUMBER : 76145-76-1 LAST UPDATED : 199612 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C21-H20-N2-O MOLECULAR WEIGHT : 316.43 WISWESSER LINE NOTATION : T B566 CN ENJ DR DO1& EY1&1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 15 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : EJDPD2 European Journal of Drug Metabolism and Pharmacokinetics. (Medecine et Hygiene, POB 229, CH-1211 Geneva 4, Switzerland) V.1- 1976- Volume(issue)/page/year: 10,161,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 10,133,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 10,133,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 10,133,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 10,133,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 1500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 10,133,1985

安全

• 海关编码: 2933990090

合成路线

76145-77-2 ~% 76145-76-1

文献：Toja; Selva; Schiatti Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 610 - 616

131-91-9 ~% 76145-76-1

文献：Toja; Selva; Schiatti Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 610 - 616

35624-23-8 ~% 76145-76-1

文献：Toja; Selva; Schiatti Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 610 - 616

123-11-5 ~% 76145-76-1

文献：Toja; Selva; Schiatti Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 610 - 616

上下游产品

上游产品  4
76145-77-2 131-91-9 35624-23-8 123-11-5
下游产品  0

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%