18910-65-1

• 常用中文名：沙甲胺醇
• 常用英文名：Salmefamol
• CAS号：18910-65-1
• 分子式：C₁₉H₂₅NO₄
• 分子量：331.40600
• 相关类别： 原料药 呼吸系统用药 平喘药
• 发布时间：2018-08-07 10:40:06
• 更新时间：2025-08-27 13:51:52
• Salmeterol is a long-acting beta2-adrenergic receptor agonist drug used in the maintenance and prevention of asthma symptoms and maintenance of chronic obstructive pulmonary disease (COPD) symptoms. Symptoms include shortness of breath, wheezing, coughing and chest tightness. Salmeterol is also used to prevent breathing difficulties during exercise (exercise induced bronchospasm). It is marketed as Serevent in the US.

名称

• 中文名: 沙甲胺醇
• 英文名: 4-[1-hydroxy-2-[1-(4-methoxyphenyl)propan-2-ylamino]ethyl]-2-(hydroxymethyl)phenol
• 英文别名: Salmefamolum [INN-Latin]; AHR 3929; AH-3923; a-((p-methoxy-a-methylphenethylamino)methyl)-4-hydroxy-m-xylene-a,a'-diol; Salmefamol; EINECS 242-662-5

物化性质

• 密度: 1.2g/cm3
• 沸点: 553.4ºC at 760mmHg
• 分子式: C₁₉H₂₅NO₄
• 分子量: 331.40600
• 闪点: 288.5ºC
• 精确质量: 331.17800
• PSA: 81.95000
• LogP: 2.53820
• 蒸汽压: 4.43E-13mmHg at 25°C
• 折射率: 1.598

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : CZ6438000 CHEMICAL NAME : 1,3-Benzenedimethanol, 4-hydroxy-alpha(sup 1)-(((2-(4-methoxyphenyl)-1-methylethyl)amino) methyl)- CAS REGISTRY NUMBER : 18910-65-1 LAST UPDATED : 199612 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C19-H25-N-O4 MOLECULAR WEIGHT : 331.45 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1925- Volume(issue)/page/year: 51,627,1975 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1925- Volume(issue)/page/year: 51,627,1975