53859-37-3

• 常用中文名：2H-1,3,2-Oxazaphosphorin-2-amine,N,N-diethyltetrahydro-, 2-oxide
• 常用英文名：2H-1,3,2-Oxazaphosphorin-2-amine,N,N-diethyltetrahydro-, 2-oxide
• CAS号：53859-37-3
• 分子式：C₇H₁₇N₂O₂P
• 分子量：192.19600
• 发布时间：2016-11-28 05:59:18
• 更新时间：2025-08-30 23:17:45

名称

• 英文名: N,N-diethyl-2-oxo-1,3,2λ5-oxazaphosphinan-2-amine
• 英文别名: Dechlorcyclophosphamide; B 516; N,N-Diethylcyclophosphamide; Didechlorocyclophosphamide; ASTA 7019; n,n-diethyl-1,3,2-oxazaphosphinan-2-amine 2-oxide; ASTA B 516

物化性质

• 密度: 1.11g/cm3
• 沸点: 249ºC at 760mmHg
• 分子式: C₇H₁₇N₂O₂P
• 分子量: 192.19600
• 闪点: 104.4ºC
• 精确质量: 192.10300
• PSA: 51.38000
• LogP: 1.77500
• 折射率: 1.473

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : RP5788700 CHEMICAL NAME : 2H-1,3,2-Oxazaphosphorin-2-amine, tetrahydro-N,N-diethyl-, 2-oxide CAS REGISTRY NUMBER : 53859-37-3 LAST UPDATED : 199612 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C7-H17-N2-O2-P MOLECULAR WEIGHT : 192.23 WISWESSER LINE NOTATION : T6MPOTJ BO BN2&2 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 350 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value MUTATION DATA TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Bird - chicken Cells - not otherwise specified DOSE/DURATION : 211 mg/kg REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 268,115,1992

安全

• 海关编码: 2934999090

合成路线

1498-54-0 156-87-6 ~% 53859-37-3

文献：Farmer; Cox Journal of Medicinal Chemistry, 1975 , vol. 18, # 11 p. 1106 - 1110

109-89-7 156-87-6 ~% 53859-37-3

文献：Zon,G. et al. Journal of the American Chemical Society, 1977 , vol. 99, p. 5785 - 5795

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上游产品  3
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海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%