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637-23-0

637-23-0结构式

常用中文名：(S,S,S)-2-氮杂双环[3,3,0]辛烷-3-羧酸苄酯盐酸盐
常用英文名：8-Azabicyclo[3.2.1]octan-3-ol,8-methyl-, benzoate (ester), hydrochloride, (3-exo)- (9CI)
CAS号：637-23-0
分子式：C₁₅H₂₀ClNO₂
分子量：281.77800
发布时间：2018-12-29 19:23:00
更新时间：2024-01-02 12:03:55

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中文名	(S,S,S)-2-氮杂双环[3,3,0]辛烷-3-羧酸苄酯盐酸盐
英文名	tropacocaine hydrochloride
英文别名	Benzoesaeure-tropan-3exo-ylester,Hydrochlorid endo-benzoic acid 8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl ester hydrochloride pseudotropine benzoate hydrochloride 3exo-benzoyloxy-tropane,hydrochloride 8-azabicyclo(3.2.1)octan-3-ol,8-methyl-,benzoate (ester),hydrochloride,ex benzoylpseudotropine hydrochloride Tropacaine hydrochloride Pseudotropin tropacocain hydrochloride 3exo-Benzoyloxy-tropan,Hydrochlorid Tropacocaine (8-methyl-8-azabicyclo[3.2.1]oct-3-yl) benzoate

沸点	339.9ºC at 760 mmHg
分子式	C₁₅H₂₀ClNO₂
分子量	281.77800
闪点	122.3ºC
精确质量	281.11800
PSA	29.54000
LogP	3.20850

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YM4201000

CHEMICAL NAME :: 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol, benzoate (ester), hydrochloride

CAS REGISTRY NUMBER :: 637-23-0

LAST UPDATED :: 198910

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C15-H19-N-O2.Cl-H

MOLECULAR WEIGHT :: 281.81

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB. Volume(issue)/page/year: 7,227,1934

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 465 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RCSADO Research Communications in Substances Abuse. (PJD Pub. Ltd., P.O.Box 966, Westbury, NY 11590) V.1- 1980- Volume(issue)/page/year: 5,279,1984

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 42 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic

REFERENCE :: WDMU** "Vergleichend-pharmakologische Untersuchungen ueber die haemolytische Wirkung und die Toxizitat der Lokalanaesthetika, Dissertation," Walther, M., Pharmakologischen Instit Martin Luther-Universitat Halle-Wittenburg, Ger. Dem. Rep., 1936 Volume(issue)/page/year: -,-,1936 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 120 mg/kg

SEX/DURATION :: female 7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System

REFERENCE :: RCSADO Research Communications in Substances Abuse. (PJD Pub. Ltd., P.O.Box 966, Westbury, NY 11590) V.1- 1980- Volume(issue)/page/year: 5,279,1984

海关编码	2933990090

98-88-4结构式

98-88-4

135-97-7结构式

135-97-7

~%

637-23-0结构式

637-23-0

文献：WO2009/34042 A1, ; Page/Page column 10-11 ;

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%