54778-22-2

• 常用中文名：2-Chloro-1-phenyl-1H-indole-3-carboxylic acid
• 常用英文名：2-Chloro-1-phenyl-1H-indole-3-carboxylic acid
• CAS号：54778-22-2
• 分子式：C₁₅H₁₀ClNO₂
• 分子量：271.69800
• 发布时间：2017-10-14 16:55:25
• 更新时间：2025-09-09 10:19:59

名称

• 英文名: 2-chloro-1-phenylindole-3-carboxylic acid
• 英文别名: 1-Phenyl-2-chloroindole-3-carboxylic acid; 2-chloro-1-phenyl-indole-3-carboxylic acid; 1H-Indole-3-carboxylic acid,2-chloro-1-phenyl; 2-Chlor-1-phenylindol-3-carbonsaeure; 2-Chloro-1-phenyl-1H-indole-3-carboxylic acid

物化性质

• 密度: 1.33g/cm3
• 沸点: 371.2ºC at 760 mmHg
• 分子式: C₁₅H₁₀ClNO₂
• 分子量: 271.69800
• 闪点: 178.3ºC
• 精确质量: 271.04000
• PSA: 42.23000
• LogP: 3.98210
• 折射率: 1.651

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NL5998504 CHEMICAL NAME : 1H-Indole-3-carboxylic acid, 2-chloro-1-phenyl- CAS REGISTRY NUMBER : 54778-22-2 BEILSTEIN REFERENCE NO. : 0481979 LAST UPDATED : 199612 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C15-H10-Cl-N-O2 MOLECULAR WEIGHT : 271.71 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 20,1344,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 20,1344,1977

合成路线

38367-40-7 ~78% 54778-22-2

文献：Aventis Pharmaceuticals Inc. Patent: US2005/54631 A1, 2005 ; Location in patent: Page/Page column 25-26 ;

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