5959-80-8

• 常用中文名：(3-methylphenyl)-[8-[3-(trifluoromethyl)phenyl]sulfonyl-1-thia-4,8-diazaspiro[4.5]decan-4-yl]methanone
• 常用英文名：(3-methylphenyl)-[8-[3-(trifluoromethyl)phenyl]sulfonyl-1-thia-4,8-diazaspiro[4.5]decan-4-yl]methanone
• CAS号：5959-80-8
• 分子式：C₂₂H₂₃F₃N₂O₃S₂
• 分子量：484.55500
• 发布时间：2017-08-02 19:16:02
• 更新时间：2024-01-10 16:50:16

名称

• 英文名: (3-methylphenyl)-[8-[3-(trifluoromethyl)phenyl]sulfonyl-1-thia-4,8-diazaspiro[4.5]decan-4-yl]methanone
• 英文别名: 2-[2-(1H-imidazol-4-yl)-ethyl]-isoindole-1,3-dione; (3-methylphenyl)-[8-[3-(trifluoromethyl)phenyl]sulfonyl-4-thia-1,8-diazaspiro[4.5]decan-1-yl]methanone; N-phthaloyl histamine; Na-phthaloylhistamine; N-[2-(1(3)H-imidazol-4-yl)-ethyl]-phthalimide; 4(5)-(2-phthalimidoethyl)imidazole

物化性质

• 密度: 1.45g/cm3
• 沸点: 634.4ºC at 760mmHg
• 分子式: C₂₂H₂₃F₃N₂O₃S₂
• 分子量: 484.55500
• 闪点: 337.5ºC
• 精确质量: 484.11000
• PSA: 91.37000
• LogP: 5.34040
• 折射率: 1.631

合成路线

22509-74-6 56-92-8 ~10% 5959-80-8

文献：Schering Corporation; Pharmacopeia Drug Discovery, Inc. Patent: EP1140909 B1, 2005 ; Location in patent: Page/Page column 73 ;

85-44-9 51-45-6 ~87% 5959-80-8

文献：Kamaraj, Kaliappan; Kim, Eunsuk; Galliker, Benedikt; Zakharov, Lev N.; Rheingold, Arnold L.; Zuberbuehler, Andreas D.; Karlin, Kenneth D. Journal of the American Chemical Society, 2003 , vol. 125, # 20 p. 6028 - 6029

22509-74-6 51-45-6 ~% 5959-80-8

文献：NOVARTIS AG; NOVARTIS PHARMA GMBH Patent: WO2005/21519 A2, 2005 ; Location in patent: Page/Page column 36 ; WO 2005/021519 A2

14997-56-9 ~20% 136918-14-4 5959-80-8

文献：Griesbeck, Axel G.; Neudoerfl, Joerg; Kiff, Alan De Beilstein Journal of Organic Chemistry, 2011 , vol. 7, p. 518 - 524

14997-56-9 ~29% 5959-80-8

文献：Sato, Yasuhiko; Nakai, Hideo; Mizoguchi, Tomishige; Kawanishi, Masazumi; Hatanaka, Yasumaru; Kanaoka, Yuichi Chemical & Pharmaceutical Bulletin, 1982 , vol. 30, # 4 p. 1263 - 1270

22509-74-6 71-00-1 ~% 136918-14-4 5959-80-8

文献：Griesbeck, Axel G.; Neudoerfl, Joerg; Kiff, Alan De Beilstein Journal of Organic Chemistry, 2011 , vol. 7, p. 518 - 524