27046-19-1

• 常用中文名：4H-1,3,2-Oxazaphosphorin-4-one,2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide
• 常用英文名：4H-1,3,2-Oxazaphosphorin-4-one,2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide
• CAS号：27046-19-1
• 分子式：C₇H₁₂Cl₂NO₄P
• 分子量：276.05400
• 发布时间：2016-12-19 04:46:11
• 更新时间：2025-08-20 23:16:19

名称

• 英文名: 2-[bis(2-chloroethyl)amino]-2-oxo-1,3,2λ5-oxazaphosphinan-4-one
• 英文别名: Oxo-Endoxan; 4-Ketocyclophosphonamid; 4-Ketocyclophosphamide; 2-(Bis(2-chloroethyl)amino)tetrahydro-4H-1,3,2-oxazaphosphorin-4-one 2-oxide; 4-ketocyclophosphamide mustard; Asta 5160; 4H-1,3,2-Oxazophosphorin-4-one,2-(bis(2-chloroethyl)amino)tetrahydro-,2-oxide; 4-Oxocyclophosphamide; 2-<Bis(2-chlorethyl)amino>-4-oxo-tetrahydro-2H-1,3,2-oxazaphosphorin-2-oxid

物化性质

• 密度: 1.42g/cm3
• 分子式: C₇H₁₂Cl₂NO₄P
• 分子量: 276.05400
• 精确质量: 274.98800
• PSA: 65.65000
• LogP: 1.49000
• 折射率: 1.515
• 储存条件: -20°C

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : RQ5857500 CHEMICAL NAME : 4H-1,3,2-Oxazophosphorin-4-one, 2-(bis(2-chloroethyl)amino)tetrahydro-, 2-oxide CAS REGISTRY NUMBER : 27046-19-1 LAST UPDATED : 199612 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C7-H13-Cl2-N2-O3-P MOLECULAR WEIGHT : 275.09 HEALTH HAZARD DATA ACUTE TOXICITY DATA MUTATION DATA TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 100 umol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 129,47,1984

合成路线

50-18-0 ~% 40277-05-2 51274-71-6 27046-19-1

文献：Struck, Robert Frederick Patent: US2010/234325 A1, 2010 ; Location in patent: Page/Page column 2 ;

78336-01-3 ~% 27046-19-1

文献：Brandt, Joan A.; Ludeman, Susan Marie; Zon, Gerald; Todhunter, John A.; Egan, William; Dickerson, Ruth Journal of Medicinal Chemistry, 1981 , vol. 24, # 12 p. 1404 - 1408

50-18-0 ~58% 27046-19-1

文献：Brandt, Joan A.; Ludeman, Susan Marie; Zon, Gerald; Todhunter, John A.; Egan, William; Dickerson, Ruth Journal of Medicinal Chemistry, 1981 , vol. 24, # 12 p. 1404 - 1408

50-18-0 ~% 22788-18-7 35144-64-0 40277-05-2 详细

文献：Wagner; Heydrich; Bartels; Hohorst Arzneimittel-Forschung, 1980 , vol. 30, # 9 p. 1588 - 1592

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