1222-57-7

• 常用中文名：佐利米定
• 常用英文名：2-(4-methylsulfonylphenyl)imidazo[1,2-a]pyridine
• CAS号：1222-57-7
• 分子式：C₁₄H₁₂N₂O₂S
• 分子量：272.32
• 发布时间：2018-08-20 20:36:48
• 更新时间：2025-08-25 13:23:40
• 唑咪啶是咪唑并吡啶的衍生物,是一种口服活性抗溃疡剂。唑胺刺激肠粘膜细胞分泌粘液,增强肠壁对溃疡的抵抗力。唑胺在十二指肠溃疡研究中显示出胃保护作用[1][2]。

名称

• 中文名: 佐利米定
• 英文名: 2-(4-methylsulfonylphenyl)imidazo[1,2-a]pyridine
• 中文别名: 甲磺苯咪啶
• 英文别名: Zolimidine; Zolimidin; EINECS 214-947-4

物化性质

• 密度: 1.31 g/cm3
• 分子式: C₁₄H₁₂N₂O₂S
• 分子量: 272.32
• 精确质量: 272.06200
• PSA: 59.82000
• LogP: 3.48560
• 折射率: 1.653

生物活性

• 描述: 唑咪啶是咪唑并吡啶的衍生物,是一种口服活性抗溃疡剂。唑胺刺激肠粘膜细胞分泌粘液,增强肠壁对溃疡的抵抗力。唑胺在十二指肠溃疡研究中显示出胃保护作用[1][2]。
• 相关类别:
  研究领域 >> 内分泌
  信号通路 >> 其他 >> 其他
• 体内研究: 唑亚胺定(200 mg/kg口服) 降低由 吲哚美辛(HY-14397)(5 mg/kg/天,持续 8.天,直肠) 诱导的大鼠肠道溃疡的发生率[2] 唑亚胺定(加在饮食中；1%含量) 可降低豚鼠由角叉菜胶 (加在饮用水中；5%含量,持续 40天) 引起的肠溃疡的发生率[2]
• 参考文献:

  [1]. Belohlavek D, et al. The effect of zolimidine, imidazopyridine-derivate, on the duodenal ulcer healing. Scand J Gastroenterol Suppl. 1979;54:44.

  [2]. Carminati GM, et al. Protective action of zolimidine against two different types of experimental intestinal ulcers. Farmaco, Edizione Pratica (1978), 33(2), 68-79.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NJ5758500 CHEMICAL NAME : Imidazo(1,2-a)pyridine, 2-(p-(methylsulfonyl)phenyl)- CAS REGISTRY NUMBER : 1222-57-7 BEILSTEIN REFERENCE NO. : 0752451 LAST UPDATED : 199712 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C14-H12-N2-O2-S MOLECULAR WEIGHT : 272.34 WISWESSER LINE NOTATION : T56 AN DNJ CR DSW1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3710 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3318880 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 950 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 33,1655,1983 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FMXXAJ French Medicament Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Discontinued. Volume(issue)/page/year: #8177M TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 765 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FMXXAJ French Medicament Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Discontinued. Volume(issue)/page/year: #8177M

安全

• 海关编码: 2933990090

合成路线

2076-70-2 ~68% 1222-57-7

文献：He, Chuan; Hao, Jing; Xu, Huan; Mo, Yiping; Liu, Huiying; Han, Juanjuan; Lei, Aiwen Chemical Communications (Cambridge, United Kingdom), 2012 , vol. 48, # 90 p. 11073 - 11075,3 Title/Abstract Full Text Show Details He, Chuan; Hao, Jing; Xu, Huan; Mo, Yiping; Liu, Huiying; Han, Juanjuan; Lei, Aiwen Chemical Communications, 2012 , vol. 48, # 90 p. 11073 - 11075

110-86-1 1562372-99-9 ~84% 1222-57-7

文献：Yu, Jipan; Jin, Yunhe; Zhang, Hao; Yang, Xiaobo; Fu, Hua Chemistry - A European Journal, 2013 , vol. 19, # 49 p. 16804 - 16808

504-29-0 56041-85-1 ~% 1222-57-7

文献：He, Chuan; Hao, Jing; Xu, Huan; Mo, Yiping; Liu, Huiying; Han, Juanjuan; Lei, Aiwen Chemical Communications (Cambridge, United Kingdom), 2012 , vol. 48, # 90 p. 11073 - 11075,3 Title/Abstract Full Text Show Details He, Chuan; Hao, Jing; Xu, Huan; Mo, Yiping; Liu, Huiying; Han, Juanjuan; Lei, Aiwen Chemical Communications, 2012 , vol. 48, # 90 p. 11073 - 11075

100-68-5 ~% 1222-57-7

文献：Mohan, Darapaneni Chandra; Donthiri, Ramachandra Reddy; Rao, Sadu Nageswara; Adimurthy, Subbarayappa Advanced Synthesis and Catalysis, 2013 , vol. 355, # 11-12 p. 2217 - 2221

504-29-0 10297-73-1 ~92% 1222-57-7

文献：Zhang, Yuhong; Zhang, Yuanfei; Chen, Zhengkai; Wu, Wenliang; Su, Weiping Journal of Organic Chemistry, 2013 , vol. 78, # 24 p. 12494 - 12504

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%